Apomorphine and 7-OH DPAT reduce ethanol intake of P and HAD rats

R. N. Russell, W. J. McBride, L. Lumeng, T. K. Li, J. M. Murphy

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Adult male rats of the alcohol-preferring (P) line (N = 10) and high alcohol drinking (HAD) line (N = 12) were used to study the effects of IP administration of 0.125-0.50 mg/kg 7-OH DPAT (a putative D3 agonist) and 0.25-1.0 mg/kg apomorphine (a dopamine agonist with 50-fold higher affinities for the D1 and D2 receptors than for the D3 receptor) on the concurrent intakes of 10% (v/v) ethanol and 0.0125% (g/v) saccharin during a daily 4-h scheduled access period. Control intakes by the P rats for the 4-h period were 17.9 ± 0.5 and 7.2 ± 0.4 ml for the ethanol and saccharin solutions, respectively. For the HAD line, ethanol consumption was 18.7 ± 0.2 ml find saccharin intake was 8.7 ± 1.6 ml for the 4-h period. In terms of grams ethanol/kg body wt., the 4-h intakes were 2.2 ± 0.2 for the P line and 3.0 ± 0.3 for the HAD rats. Both P and HAD rats consumed approximately 40% of their total ethanol intake in the first 15 min of access while consuming only about 15% of their total saccharin intake during this 15-min period. The putative D3 agonist 7-OH DPAT produced a decrease in ethanol intake in the first h to 45-55% of control levels for the P rat (p < 0.01) and to 25-70% of control values in the HAD line (p < 0.001). Apomorphine caused a dose- dependent decrease in ethanol intake in the first hour to 15-70% of control values in the P rat (p < 0.001) and to 25-60% of control levels in the HAD line (p < 0.001). Saccharin and 4-h food intakes for both lines were not altered by either 7-OH DPAT or apomorphine. Overall, these results suggest that D2 and D3 dopamine receptors may play a role in mediating alcohol drinking behavior of the selectively bred HAD and P lines of rats.

Original languageEnglish
Pages (from-to)515-519
Number of pages5
JournalAlcohol
Volume13
Issue number5
DOIs
StatePublished - Sep 1996

Fingerprint

Apomorphine
Alcohol Drinking
Rats
Saccharin
Ethanol
alcohol
Alcohols
Level control
Dopamine D3 Receptors
Drinking Behavior
Dopamine D2 Receptors
7-hydroxy-2-N,N-dipropylaminotetralin
Dopamine Agonists
Eating
Values
food

Keywords

  • 7-OH DPAT
  • Alcohol preference
  • Apomorphine
  • Dopamine D receptor
  • Dopamine D receptor

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Behavioral Neuroscience
  • Neuroscience(all)
  • Toxicology
  • Health(social science)

Cite this

Russell, R. N., McBride, W. J., Lumeng, L., Li, T. K., & Murphy, J. M. (1996). Apomorphine and 7-OH DPAT reduce ethanol intake of P and HAD rats. Alcohol, 13(5), 515-519. https://doi.org/10.1016/0741-8329(95)00062-3

Apomorphine and 7-OH DPAT reduce ethanol intake of P and HAD rats. / Russell, R. N.; McBride, W. J.; Lumeng, L.; Li, T. K.; Murphy, J. M.

In: Alcohol, Vol. 13, No. 5, 09.1996, p. 515-519.

Research output: Contribution to journalArticle

Russell, RN, McBride, WJ, Lumeng, L, Li, TK & Murphy, JM 1996, 'Apomorphine and 7-OH DPAT reduce ethanol intake of P and HAD rats', Alcohol, vol. 13, no. 5, pp. 515-519. https://doi.org/10.1016/0741-8329(95)00062-3
Russell RN, McBride WJ, Lumeng L, Li TK, Murphy JM. Apomorphine and 7-OH DPAT reduce ethanol intake of P and HAD rats. Alcohol. 1996 Sep;13(5):515-519. https://doi.org/10.1016/0741-8329(95)00062-3
Russell, R. N. ; McBride, W. J. ; Lumeng, L. ; Li, T. K. ; Murphy, J. M. / Apomorphine and 7-OH DPAT reduce ethanol intake of P and HAD rats. In: Alcohol. 1996 ; Vol. 13, No. 5. pp. 515-519.
@article{34517db8e3de4d618a0f55e42be4d088,
title = "Apomorphine and 7-OH DPAT reduce ethanol intake of P and HAD rats",
abstract = "Adult male rats of the alcohol-preferring (P) line (N = 10) and high alcohol drinking (HAD) line (N = 12) were used to study the effects of IP administration of 0.125-0.50 mg/kg 7-OH DPAT (a putative D3 agonist) and 0.25-1.0 mg/kg apomorphine (a dopamine agonist with 50-fold higher affinities for the D1 and D2 receptors than for the D3 receptor) on the concurrent intakes of 10{\%} (v/v) ethanol and 0.0125{\%} (g/v) saccharin during a daily 4-h scheduled access period. Control intakes by the P rats for the 4-h period were 17.9 ± 0.5 and 7.2 ± 0.4 ml for the ethanol and saccharin solutions, respectively. For the HAD line, ethanol consumption was 18.7 ± 0.2 ml find saccharin intake was 8.7 ± 1.6 ml for the 4-h period. In terms of grams ethanol/kg body wt., the 4-h intakes were 2.2 ± 0.2 for the P line and 3.0 ± 0.3 for the HAD rats. Both P and HAD rats consumed approximately 40{\%} of their total ethanol intake in the first 15 min of access while consuming only about 15{\%} of their total saccharin intake during this 15-min period. The putative D3 agonist 7-OH DPAT produced a decrease in ethanol intake in the first h to 45-55{\%} of control levels for the P rat (p < 0.01) and to 25-70{\%} of control values in the HAD line (p < 0.001). Apomorphine caused a dose- dependent decrease in ethanol intake in the first hour to 15-70{\%} of control values in the P rat (p < 0.001) and to 25-60{\%} of control levels in the HAD line (p < 0.001). Saccharin and 4-h food intakes for both lines were not altered by either 7-OH DPAT or apomorphine. Overall, these results suggest that D2 and D3 dopamine receptors may play a role in mediating alcohol drinking behavior of the selectively bred HAD and P lines of rats.",
keywords = "7-OH DPAT, Alcohol preference, Apomorphine, Dopamine D receptor, Dopamine D receptor",
author = "Russell, {R. N.} and McBride, {W. J.} and L. Lumeng and Li, {T. K.} and Murphy, {J. M.}",
year = "1996",
month = "9",
doi = "10.1016/0741-8329(95)00062-3",
language = "English",
volume = "13",
pages = "515--519",
journal = "Alcohol",
issn = "0741-8329",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Apomorphine and 7-OH DPAT reduce ethanol intake of P and HAD rats

AU - Russell, R. N.

AU - McBride, W. J.

AU - Lumeng, L.

AU - Li, T. K.

AU - Murphy, J. M.

PY - 1996/9

Y1 - 1996/9

N2 - Adult male rats of the alcohol-preferring (P) line (N = 10) and high alcohol drinking (HAD) line (N = 12) were used to study the effects of IP administration of 0.125-0.50 mg/kg 7-OH DPAT (a putative D3 agonist) and 0.25-1.0 mg/kg apomorphine (a dopamine agonist with 50-fold higher affinities for the D1 and D2 receptors than for the D3 receptor) on the concurrent intakes of 10% (v/v) ethanol and 0.0125% (g/v) saccharin during a daily 4-h scheduled access period. Control intakes by the P rats for the 4-h period were 17.9 ± 0.5 and 7.2 ± 0.4 ml for the ethanol and saccharin solutions, respectively. For the HAD line, ethanol consumption was 18.7 ± 0.2 ml find saccharin intake was 8.7 ± 1.6 ml for the 4-h period. In terms of grams ethanol/kg body wt., the 4-h intakes were 2.2 ± 0.2 for the P line and 3.0 ± 0.3 for the HAD rats. Both P and HAD rats consumed approximately 40% of their total ethanol intake in the first 15 min of access while consuming only about 15% of their total saccharin intake during this 15-min period. The putative D3 agonist 7-OH DPAT produced a decrease in ethanol intake in the first h to 45-55% of control levels for the P rat (p < 0.01) and to 25-70% of control values in the HAD line (p < 0.001). Apomorphine caused a dose- dependent decrease in ethanol intake in the first hour to 15-70% of control values in the P rat (p < 0.001) and to 25-60% of control levels in the HAD line (p < 0.001). Saccharin and 4-h food intakes for both lines were not altered by either 7-OH DPAT or apomorphine. Overall, these results suggest that D2 and D3 dopamine receptors may play a role in mediating alcohol drinking behavior of the selectively bred HAD and P lines of rats.

AB - Adult male rats of the alcohol-preferring (P) line (N = 10) and high alcohol drinking (HAD) line (N = 12) were used to study the effects of IP administration of 0.125-0.50 mg/kg 7-OH DPAT (a putative D3 agonist) and 0.25-1.0 mg/kg apomorphine (a dopamine agonist with 50-fold higher affinities for the D1 and D2 receptors than for the D3 receptor) on the concurrent intakes of 10% (v/v) ethanol and 0.0125% (g/v) saccharin during a daily 4-h scheduled access period. Control intakes by the P rats for the 4-h period were 17.9 ± 0.5 and 7.2 ± 0.4 ml for the ethanol and saccharin solutions, respectively. For the HAD line, ethanol consumption was 18.7 ± 0.2 ml find saccharin intake was 8.7 ± 1.6 ml for the 4-h period. In terms of grams ethanol/kg body wt., the 4-h intakes were 2.2 ± 0.2 for the P line and 3.0 ± 0.3 for the HAD rats. Both P and HAD rats consumed approximately 40% of their total ethanol intake in the first 15 min of access while consuming only about 15% of their total saccharin intake during this 15-min period. The putative D3 agonist 7-OH DPAT produced a decrease in ethanol intake in the first h to 45-55% of control levels for the P rat (p < 0.01) and to 25-70% of control values in the HAD line (p < 0.001). Apomorphine caused a dose- dependent decrease in ethanol intake in the first hour to 15-70% of control values in the P rat (p < 0.001) and to 25-60% of control levels in the HAD line (p < 0.001). Saccharin and 4-h food intakes for both lines were not altered by either 7-OH DPAT or apomorphine. Overall, these results suggest that D2 and D3 dopamine receptors may play a role in mediating alcohol drinking behavior of the selectively bred HAD and P lines of rats.

KW - 7-OH DPAT

KW - Alcohol preference

KW - Apomorphine

KW - Dopamine D receptor

KW - Dopamine D receptor

UR - http://www.scopus.com/inward/record.url?scp=0030249190&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030249190&partnerID=8YFLogxK

U2 - 10.1016/0741-8329(95)00062-3

DO - 10.1016/0741-8329(95)00062-3

M3 - Article

C2 - 8888949

AN - SCOPUS:0030249190

VL - 13

SP - 515

EP - 519

JO - Alcohol

JF - Alcohol

SN - 0741-8329

IS - 5

ER -