Apoptosis in anthracycline cardiomyopathy

Jianjian Shi, Eltyeb Abdelwahid, Lei Wei

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Apoptosis is a tightly regulated physiologic process of programmed cell death that occurs in both normal and pathologic tissues. Numerous in vitro or in vivo studies have indicated that cardiomyocyte death through apoptosis and necrosis is a primary contributor to the progression of anthracycline-induced cardiomyopathy. There are now several pieces of evidence to suggest that activation of intrinsic and extrinsic apoptotic pathways contribute to anthracyclineinduced apoptosis in the heart. Novel strategies were developed to address a wide variety of cardiotoxic mechanisms and apoptotic pathways by which anthracycline influences cardiac structure and function. Anthracycline-induced apoptosis provides a very valid representation of cardiotoxicity in the heart, an argument which has implications for the most appropriate animal models of damaged heart plus diverse pharmacological effects. In this review we describe various aspects of the current understanding of apoptotic cell death triggered by anthracycline. Differences in the sensitivity to anthracycline-induced apoptosis between young and adult hearts are also discussed.

Original languageEnglish
Pages (from-to)329-336
Number of pages8
JournalCurrent Pediatric Reviews
Volume7
Issue number4
DOIs
StatePublished - Nov 2011

Fingerprint

Anthracyclines
Cardiomyopathies
Apoptosis
Cell Death
Cardiac Myocytes
Young Adult
Necrosis
Animal Models
Pharmacology

Keywords

  • Anthracycline
  • Apoptosis
  • Cardiomyopathy
  • Pediatric

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Apoptosis in anthracycline cardiomyopathy. / Shi, Jianjian; Abdelwahid, Eltyeb; Wei, Lei.

In: Current Pediatric Reviews, Vol. 7, No. 4, 11.2011, p. 329-336.

Research output: Contribution to journalArticle

Shi, Jianjian ; Abdelwahid, Eltyeb ; Wei, Lei. / Apoptosis in anthracycline cardiomyopathy. In: Current Pediatric Reviews. 2011 ; Vol. 7, No. 4. pp. 329-336.
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