Apoptosis in the liver

Ying Hong Shi, Jia Fan, Zhen Bin Ding, Xiao-Ming Yin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Apoptosis is important for the regulation of many physiological and pathological processes. The molecular machinery of apoptosis is composed of the death receptor pathway (extrinsic), the mitochondrial pathway (intrinsic), and other complicated signaling networks. In the death receptor pathway, following ligands binding to the receptors, intracellular adaptor molecules are recruited to the receptor and subsequently the apoptotic signal is transmitted. In the mitochondrial pathway, apoptotic signals trigger the release of mitochondrial apoptogenic factors and mitochondrial dysfunction. Apoptosis signaling pathway can be abnormally activated in various pathological processes in the liver, including acute and chronic hepatitis, fibrogenesis, liver cirrhosis and liver carcinogenesis. Thus delineation of apoptosis mechanisms has brought out new paradigms of understanding in the pathogenesis of liver diseases. Inhibition of apoptosis could reverse liver injury by blocking the death process. Hence, dissection of the mechanisms in apoptosis underlying liver diseases would provide the basis of novel therapeutic strategies.

Original languageEnglish (US)
Title of host publicationApoptosis
Subtitle of host publicationModern Insights into Disease from Molecules to Man
PublisherCRC Press
Pages197-212
Number of pages16
ISBN (Electronic)9781439845431
ISBN (Print)9781578085835
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Shi, Y. H., Fan, J., Ding, Z. B., & Yin, X-M. (2010). Apoptosis in the liver. In Apoptosis: Modern Insights into Disease from Molecules to Man (pp. 197-212). CRC Press. https://doi.org/10.1201/9781439845431