Apoptosis-induced inhibition of CD1d-mediated antigen presentation

Different roles for caspases and signal transduction pathways

Masood A. Khan, Venkataraman Sriram, Gourapura J. Renukaradhya, Wenjun Du, Jacquelyn Gervay-Hague, Randy Brutkiewicz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The stimulation of programmed cell death can either enhance or inhibit antigen presentation by classic major histocompatibility complex molecules. In the current study, we report that the induction of apoptosis by topoisomerase I inhibition or elevation of intracellular ceramide levels substantially impairs CD1d-mediated antigen presentation. In the former case, such a reduction occurred via the regulation of both the p38 mitogen-activated protein kinases and protein kinase C δ signal transduction pathways as well as the caspase cascade, whereas the latter was p38-(but not caspase)-dependent. Confocal microscopic analysis showed an altered intracellular distribution of CD1d following the inhibition topoisomerase I or by an increase in intracellular ceramide levels, that was prevented by p38 and caspase inhibitors. Thus, the induction of apoptosis in antigen presenting cells severely compromises CD1d-mediated antigen presentation by multiple mechanisms.

Original languageEnglish
Pages (from-to)80-90
Number of pages11
JournalImmunology
Volume125
Issue number1
DOIs
StatePublished - Sep 2008

Fingerprint

CD1d Antigen
Antigen Presentation
Caspases
Signal Transduction
Type I DNA Topoisomerase
Ceramides
p38 Mitogen-Activated Protein Kinases
Apoptosis
Caspase Inhibitors
Mitogen-Activated Protein Kinase Kinases
Antigen-Presenting Cells
Major Histocompatibility Complex
Protein Kinase C
Cell Death

Keywords

  • Antigen presentation/processing
  • Apoptosis
  • Signal transduction

ASJC Scopus subject areas

  • Immunology

Cite this

Apoptosis-induced inhibition of CD1d-mediated antigen presentation : Different roles for caspases and signal transduction pathways. / Khan, Masood A.; Sriram, Venkataraman; Renukaradhya, Gourapura J.; Du, Wenjun; Gervay-Hague, Jacquelyn; Brutkiewicz, Randy.

In: Immunology, Vol. 125, No. 1, 09.2008, p. 80-90.

Research output: Contribution to journalArticle

Khan, Masood A. ; Sriram, Venkataraman ; Renukaradhya, Gourapura J. ; Du, Wenjun ; Gervay-Hague, Jacquelyn ; Brutkiewicz, Randy. / Apoptosis-induced inhibition of CD1d-mediated antigen presentation : Different roles for caspases and signal transduction pathways. In: Immunology. 2008 ; Vol. 125, No. 1. pp. 80-90.
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