Apoptosis of Bone Cells

Robert L. Jilka, Teresita Bellido, Maria Almeida, Lilian Plotkin, Charles A. O'Brien, Robert S. Weinstein, Stavros C. Manolagas

Research output: Chapter in Book/Report/Conference proceedingChapter

19 Citations (Scopus)

Abstract

This chapter describes the phenomenon of apoptosis of bone cells. Apoptosis is controlled by a variety of physiological and pathological factors and is involved in the control of cell number during development, repair, and maintenance of regenerating epithelial tissues. This chapter begins by describing general features of apoptosis and its regulation. It then focuses on the occurrence and control of apoptosis in chondrocytes, osteoclasts, osteoblasts, and osteocytes. Furthermore, it highlights the role of apoptosis of osteoclasts and osteoblasts during remodeling by the basic multicellular unit (BMU), the role of osteocyte apoptosis in adaptation to mechanical strain, and the significance of bone cell apoptosis in the pathophysiology of bone disease and its treatment. Apoptosis of chondrocytes, osteoclasts, osteoblasts, and osteocytes plays a critical role in the development of the skeleton and in the maintenance of bone mass and strength throughout life. Dysregulation of bone cell apoptosis contributes to joint disease, as well as to the development of osteoporosis that occurs with sex steroid deficiency, glucocorticoid excess, and aging. Apoptosis may also be an important therapeutic target because the beneficial effects of intermittent parathyroid hormone are associated with a reduction in osteoblast and osteocyte apoptosis. Future innovations that facilitate detection of this important event in human bone, as well as a deeper understanding of the factors and signaling pathways that control bone cell survival, should provide a better appreciation of the role of apoptosis in bone physiology, pathophysiology, and treatment.

Original languageEnglish (US)
Title of host publicationPrinciples of Bone Biology, Two-Volume Set
PublisherElsevier Inc.
Pages237-261
Number of pages25
Volume1
ISBN (Print)9780123738844
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

Bone
Apoptosis
Bone and Bones
Osteocytes
Osteoblasts
Osteoclasts
Chondrocytes
Maintenance
Joint Diseases
Bone Diseases
Physiology
Parathyroid Hormone
Skeleton
Glucocorticoids
Osteoporosis
Cell Survival
Repair
Epithelium
Cell Count
Innovation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Jilka, R. L., Bellido, T., Almeida, M., Plotkin, L., O'Brien, C. A., Weinstein, R. S., & Manolagas, S. C. (2008). Apoptosis of Bone Cells. In Principles of Bone Biology, Two-Volume Set (Vol. 1, pp. 237-261). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-373884-4.00032-X

Apoptosis of Bone Cells. / Jilka, Robert L.; Bellido, Teresita; Almeida, Maria; Plotkin, Lilian; O'Brien, Charles A.; Weinstein, Robert S.; Manolagas, Stavros C.

Principles of Bone Biology, Two-Volume Set. Vol. 1 Elsevier Inc., 2008. p. 237-261.

Research output: Chapter in Book/Report/Conference proceedingChapter

Jilka, RL, Bellido, T, Almeida, M, Plotkin, L, O'Brien, CA, Weinstein, RS & Manolagas, SC 2008, Apoptosis of Bone Cells. in Principles of Bone Biology, Two-Volume Set. vol. 1, Elsevier Inc., pp. 237-261. https://doi.org/10.1016/B978-0-12-373884-4.00032-X
Jilka RL, Bellido T, Almeida M, Plotkin L, O'Brien CA, Weinstein RS et al. Apoptosis of Bone Cells. In Principles of Bone Biology, Two-Volume Set. Vol. 1. Elsevier Inc. 2008. p. 237-261 https://doi.org/10.1016/B978-0-12-373884-4.00032-X
Jilka, Robert L. ; Bellido, Teresita ; Almeida, Maria ; Plotkin, Lilian ; O'Brien, Charles A. ; Weinstein, Robert S. ; Manolagas, Stavros C. / Apoptosis of Bone Cells. Principles of Bone Biology, Two-Volume Set. Vol. 1 Elsevier Inc., 2008. pp. 237-261
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