Apoptosis of CD57+ and CD57- lymphocytes in the lung and blood of HIV-infected subjects

Karen L. Wood, Kenneth S. Knox, Yana Wang, Richard B. Day, Carol Schnizlein-Bick, Homer Twigg

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Patients infected with HIV frequently have a CD8+ lymphocytic alveolitis consisting of HIV-specific CD8+CD57- cytotoxic T lymphocytes. However, in late stage disease, there is expansion of a CD8+CD57+ population with suppressive properties. We examined role of lymphocyte apoptosis in the expansion of the CD8+CD57+ lymphocytes in late stage HIV in the lung and blood compartment in human subjects. Fas was expressed on virtually all lung lymphocytes from HIV-infected and normal subjects. Fas ligand expression was increased in HIV infection in both CD8+CD57+ and CD8+CD57- lymphocytes, though a significantly greater percentage of CD8+CD57+ cells expressed this marker. CD8+CD57+ lymphocytes in normal and HIV-infected subjects underwent more apoptosis than CD8+CD57- cells. However, in late stage HIV infection, the percentage of CD8+CD57+ cells undergoing apoptosis declined. These data demonstrate that under normal conditions CD8+CD57+ cells appear destined to undergo programmed cell death. Expansion of suppressive CD8+CD57+ cells in the lungs of HIV-infected subjects with advanced disease may be due to the failure of this normal regulatory process.

Original languageEnglish
Pages (from-to)294-301
Number of pages8
JournalClinical Immunology
Volume117
Issue number3
DOIs
StatePublished - Dec 2005

Fingerprint

HIV
Lymphocytes
Apoptosis
Lung
HIV Infections
Fas Ligand Protein
Cytotoxic T-Lymphocytes
Cell Death
Population

Keywords

  • Apoptosis
  • Human
  • Lung
  • T lymphocytes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Apoptosis of CD57+ and CD57- lymphocytes in the lung and blood of HIV-infected subjects. / Wood, Karen L.; Knox, Kenneth S.; Wang, Yana; Day, Richard B.; Schnizlein-Bick, Carol; Twigg, Homer.

In: Clinical Immunology, Vol. 117, No. 3, 12.2005, p. 294-301.

Research output: Contribution to journalArticle

Wood, Karen L. ; Knox, Kenneth S. ; Wang, Yana ; Day, Richard B. ; Schnizlein-Bick, Carol ; Twigg, Homer. / Apoptosis of CD57+ and CD57- lymphocytes in the lung and blood of HIV-infected subjects. In: Clinical Immunology. 2005 ; Vol. 117, No. 3. pp. 294-301.
@article{b18ffdd6b98949a295e4dcd6c250fd7c,
title = "Apoptosis of CD57+ and CD57- lymphocytes in the lung and blood of HIV-infected subjects",
abstract = "Patients infected with HIV frequently have a CD8+ lymphocytic alveolitis consisting of HIV-specific CD8+CD57- cytotoxic T lymphocytes. However, in late stage disease, there is expansion of a CD8+CD57+ population with suppressive properties. We examined role of lymphocyte apoptosis in the expansion of the CD8+CD57+ lymphocytes in late stage HIV in the lung and blood compartment in human subjects. Fas was expressed on virtually all lung lymphocytes from HIV-infected and normal subjects. Fas ligand expression was increased in HIV infection in both CD8+CD57+ and CD8+CD57- lymphocytes, though a significantly greater percentage of CD8+CD57+ cells expressed this marker. CD8+CD57+ lymphocytes in normal and HIV-infected subjects underwent more apoptosis than CD8+CD57- cells. However, in late stage HIV infection, the percentage of CD8+CD57+ cells undergoing apoptosis declined. These data demonstrate that under normal conditions CD8+CD57+ cells appear destined to undergo programmed cell death. Expansion of suppressive CD8+CD57+ cells in the lungs of HIV-infected subjects with advanced disease may be due to the failure of this normal regulatory process.",
keywords = "Apoptosis, Human, Lung, T lymphocytes",
author = "Wood, {Karen L.} and Knox, {Kenneth S.} and Yana Wang and Day, {Richard B.} and Carol Schnizlein-Bick and Homer Twigg",
year = "2005",
month = "12",
doi = "10.1016/j.clim.2005.09.009",
language = "English",
volume = "117",
pages = "294--301",
journal = "Clinical Immunology",
issn = "1521-6616",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Apoptosis of CD57+ and CD57- lymphocytes in the lung and blood of HIV-infected subjects

AU - Wood, Karen L.

AU - Knox, Kenneth S.

AU - Wang, Yana

AU - Day, Richard B.

AU - Schnizlein-Bick, Carol

AU - Twigg, Homer

PY - 2005/12

Y1 - 2005/12

N2 - Patients infected with HIV frequently have a CD8+ lymphocytic alveolitis consisting of HIV-specific CD8+CD57- cytotoxic T lymphocytes. However, in late stage disease, there is expansion of a CD8+CD57+ population with suppressive properties. We examined role of lymphocyte apoptosis in the expansion of the CD8+CD57+ lymphocytes in late stage HIV in the lung and blood compartment in human subjects. Fas was expressed on virtually all lung lymphocytes from HIV-infected and normal subjects. Fas ligand expression was increased in HIV infection in both CD8+CD57+ and CD8+CD57- lymphocytes, though a significantly greater percentage of CD8+CD57+ cells expressed this marker. CD8+CD57+ lymphocytes in normal and HIV-infected subjects underwent more apoptosis than CD8+CD57- cells. However, in late stage HIV infection, the percentage of CD8+CD57+ cells undergoing apoptosis declined. These data demonstrate that under normal conditions CD8+CD57+ cells appear destined to undergo programmed cell death. Expansion of suppressive CD8+CD57+ cells in the lungs of HIV-infected subjects with advanced disease may be due to the failure of this normal regulatory process.

AB - Patients infected with HIV frequently have a CD8+ lymphocytic alveolitis consisting of HIV-specific CD8+CD57- cytotoxic T lymphocytes. However, in late stage disease, there is expansion of a CD8+CD57+ population with suppressive properties. We examined role of lymphocyte apoptosis in the expansion of the CD8+CD57+ lymphocytes in late stage HIV in the lung and blood compartment in human subjects. Fas was expressed on virtually all lung lymphocytes from HIV-infected and normal subjects. Fas ligand expression was increased in HIV infection in both CD8+CD57+ and CD8+CD57- lymphocytes, though a significantly greater percentage of CD8+CD57+ cells expressed this marker. CD8+CD57+ lymphocytes in normal and HIV-infected subjects underwent more apoptosis than CD8+CD57- cells. However, in late stage HIV infection, the percentage of CD8+CD57+ cells undergoing apoptosis declined. These data demonstrate that under normal conditions CD8+CD57+ cells appear destined to undergo programmed cell death. Expansion of suppressive CD8+CD57+ cells in the lungs of HIV-infected subjects with advanced disease may be due to the failure of this normal regulatory process.

KW - Apoptosis

KW - Human

KW - Lung

KW - T lymphocytes

UR - http://www.scopus.com/inward/record.url?scp=29344439168&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29344439168&partnerID=8YFLogxK

U2 - 10.1016/j.clim.2005.09.009

DO - 10.1016/j.clim.2005.09.009

M3 - Article

VL - 117

SP - 294

EP - 301

JO - Clinical Immunology

JF - Clinical Immunology

SN - 1521-6616

IS - 3

ER -