Application of nanoelectrodes in recording biopotentials

A. G. Akingba, D. Wang, Peng-Sheng Chen, H. Neves, C. Montemagno

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Previous attempts at directly recording sympathetic activity using wire electrodes without significant filtering have yielded poor signal-to-noise ratio. This is because the amplitude of the signal from a sympathetic nerve is typically -35 to +35 μV and the electrode noise is on average 10 μV for an ideal electrode resistance between 100 kΩ and 10 MΩ at 37°C for a bandwith of 1 kHz. We hypothesized that if we fabricated an electrode with increased nervous tissue surface contact that was sharp enough to penetrate the epineurium without damaging sympathetic neurons we would improve our signal-to-noise ratio and therefore be able to record high fidelity sympathetic activity. We built an array of nano-sized rods on a silicon substrate using a combination of micro- and nanofabrication techniques. Afterwards, we patterned and deposited aluminum on the surface of our processed silicon substrate in order to form a bipolar biopotential electrode with a three-dimensional surface. At this time our fabrication technique did not include a passivation layer. This configuration allowed us to examine the performance of a bipolar electrode without much of the effects related to the parasitic capacitance. The signal-to-noise ratio of our recordings in wet media were similar for both the wire electrde and the bipolar nanoelectrode array. Finally, we were able to record stimulated nerve activity when the bipolar nanoelectrode array was placed on the cardiac sympathetic nerve of an anesthetized animal.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE Conference on Nanotechnology
PublisherIEEE Computer Society
Pages870-874
Number of pages5
Volume2
ISBN (Print)0780379764
DOIs
StatePublished - 2003
Externally publishedYes
Event2003 3rd IEEE Conference on Nanotechnology, IEEE-NANO 2003 - San Francisco, United States
Duration: Aug 12 2003Aug 14 2003

Other

Other2003 3rd IEEE Conference on Nanotechnology, IEEE-NANO 2003
CountryUnited States
CitySan Francisco
Period8/12/038/14/03

Fingerprint

recording
Electrodes
electrodes
nerves
Signal to noise ratio
signal to noise ratios
Silicon
wire
Wire
nanofabrication
Microfabrication
silicon
Substrates
Aluminum
neurons
Nanotechnology
Passivation
passivity
Neurons
animals

Keywords

  • Electrodes
  • Filtering
  • Immune system
  • Nanofabrication
  • Neurons
  • Noise level
  • Signal to noise ratio
  • Silicon
  • Surface resistance
  • Wire

ASJC Scopus subject areas

  • Bioengineering
  • Electrical and Electronic Engineering
  • Materials Chemistry
  • Condensed Matter Physics

Cite this

Akingba, A. G., Wang, D., Chen, P-S., Neves, H., & Montemagno, C. (2003). Application of nanoelectrodes in recording biopotentials. In Proceedings of the IEEE Conference on Nanotechnology (Vol. 2, pp. 870-874). [1231053] IEEE Computer Society. https://doi.org/10.1109/NANO.2003.1231053

Application of nanoelectrodes in recording biopotentials. / Akingba, A. G.; Wang, D.; Chen, Peng-Sheng; Neves, H.; Montemagno, C.

Proceedings of the IEEE Conference on Nanotechnology. Vol. 2 IEEE Computer Society, 2003. p. 870-874 1231053.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Akingba, AG, Wang, D, Chen, P-S, Neves, H & Montemagno, C 2003, Application of nanoelectrodes in recording biopotentials. in Proceedings of the IEEE Conference on Nanotechnology. vol. 2, 1231053, IEEE Computer Society, pp. 870-874, 2003 3rd IEEE Conference on Nanotechnology, IEEE-NANO 2003, San Francisco, United States, 8/12/03. https://doi.org/10.1109/NANO.2003.1231053
Akingba AG, Wang D, Chen P-S, Neves H, Montemagno C. Application of nanoelectrodes in recording biopotentials. In Proceedings of the IEEE Conference on Nanotechnology. Vol. 2. IEEE Computer Society. 2003. p. 870-874. 1231053 https://doi.org/10.1109/NANO.2003.1231053
Akingba, A. G. ; Wang, D. ; Chen, Peng-Sheng ; Neves, H. ; Montemagno, C. / Application of nanoelectrodes in recording biopotentials. Proceedings of the IEEE Conference on Nanotechnology. Vol. 2 IEEE Computer Society, 2003. pp. 870-874
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