Application of the Milan System for Reporting Salivary Gland Cytopathology

A Retrospective 12-Year Bi-institutional Study

Howard Wu, Fatimah Alruwaii, Bao Rung Zeng, Harvey Cramer, Chiung Ru Lai, Jen Fan Hang

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: Multi-institutional studies are required for the validation of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC). METHODS: A total of 1,560 fine-needle aspirations of the salivary glands were retrieved from two institutions for a 12-year period. The diagnoses were reclassified based on the MSRSGC. Risk of malignancy (ROM) for each category was calculated based on 694 histologic follow-up cases. RESULTS: The ROM for each category was: 18.3% for nondiagnostic, 8.9% for nonneoplastic, 37.5% for atypia of undetermined significance (AUS), 2.9% for benign neoplasm, 40.7% for salivary gland neoplasm of uncertain malignant potential (SUMP), 100% for suspicious for malignancy, and 98.3% for malignant. The sensitivity, specificity, positive predictive rate, and negative predictive rates were 89%, 99%, 98%, and 96%, respectively. CONCLUSIONS: The results of the current study are in keeping with the MSRSGC. The indeterminate categories of AUS and SUMP showed intermediate ROMs at 37.5% and 40.7%, respectively.

Original languageEnglish (US)
Pages (from-to)613-621
Number of pages9
JournalAmerican journal of clinical pathology
Volume151
Issue number6
DOIs
StatePublished - May 3 2019

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Salivary Glands
Salivary Gland Neoplasms
Neoplasms
Validation Studies
Fine Needle Biopsy
Sensitivity and Specificity

Keywords

  • Cytology
  • Fine needle aspiration (FNA)
  • Milan System for Reporting Salivary Gland Cytopathology (MSRSGC)
  • Risk of malignancy (ROM)
  • Salivary gland

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Application of the Milan System for Reporting Salivary Gland Cytopathology : A Retrospective 12-Year Bi-institutional Study. / Wu, Howard; Alruwaii, Fatimah; Zeng, Bao Rung; Cramer, Harvey; Lai, Chiung Ru; Hang, Jen Fan.

In: American journal of clinical pathology, Vol. 151, No. 6, 03.05.2019, p. 613-621.

Research output: Contribution to journalArticle

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