Application of the Milan System for Reporting Salivary Gland Cytopathology: A Retrospective 12-Year Bi-institutional Study

Howard H. Wu, Fatimah Alruwaii, Bao Rung Zeng, Harvey M. Cramer, Chiung Ru Lai, Jen Fan Hang

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Objectives: Multi-institutional studies are required for the validation of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC). Methods: A total of 1,560 fine-needle aspirations of the salivary glands were retrieved from two institutions for a 12-year period. The diagnoses were reclassified based on the MSRSGC. Risk of malignancy (ROM) for each category was calculated based on 694 histologic follow-up cases. Results: The ROM for each category was: 18.3% for nondiagnostic, 8.9% for nonneoplastic, 37.5% for atypia of undetermined significance (AUS), 2.9% for benign neoplasm, 40.7% for salivary gland neoplasm of uncertain malignant potential (SUMP), 100% for suspicious for malignancy, and 98.3% for malignant. The sensitivity, specificity, positive predictive rate, and negative predictive rates were 89%, 99%, 98%, and 96%, respectively. Conclusions: The results of the current study are in keeping with the MSRSGC. The indeterminate categories of AUS and SUMP showed intermediate ROMs at 37.5% and 40.7%, respectively.

Original languageEnglish (US)
Pages (from-to)613-621
Number of pages9
JournalAmerican journal of clinical pathology
Volume151
Issue number6
DOIs
StatePublished - Jan 1 2019

Keywords

  • Cytology
  • Fine needle aspiration (FNA)
  • Milan System for Reporting Salivary Gland Cytopathology (MSRSGC)
  • Risk of malignancy (ROM)
  • Salivary gland

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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