Application of time-resolved angiography with stochastic trajectories (twist)-dixon in dynamic contrast-enhanced (dce) breast mri

Yuan Le, Hal Kipfer, Shadie Majidi, Stephanie Holz, Brian Dale, Christian Geppert, Randall Kroeker, Chen Lin

Research output: Contribution to journalArticle

20 Scopus citations


Purpose To evaluate a magnetic resonance imaging (MRI) technique that integrates time-resolved angiography with stochastic trajectories (TWIST) view sharing and Dixon for a breast dynamic contrast-enhanced (DCE)-MRI application. Materials and Methods Simulation study: K-space data at six timepoints (1 pre-, 5 postcontrast) were generated by performing Fourier transform on a digital "phantom" with 3-9 mm enhancing lesions and three types of enhancement curves (persistent, plateau, washout). Images were reconstructed with and without TWIST. Clinical study: Six TWIST-Dixon image sets (one pre-, five postcontrast) were acquired in 18 patients on a 3T scanner, followed by one conventional image set. The last TWIST-Dixon and the conventional images were scored for seven criteria: perceived signal-to-noise ratio (P.SNR), visualization of anatomy, fat suppression (FS) accuracy, FS uniformity, ghosting artifact, edge ringing artifact, and overall image quality (IQ). Results Simulation study: With proper TWIST parameters (pA ≥33%, pB ≥50%), the enhancement underestimation was 5% or less for tumor size ≥5 mm. Clinical study: TWIST-Dixon images have significantly better scores in all criteria except for ghosting artifacts, where the difference was not significant. Conclusion With proper parameters, TWIST-Dixon provides higher perceived SNR, more accurate fat suppression, and better overall image quality for breast DCE-MRI without sacrificing accuracy in the enhancement estimation. J. Magn. Reson. Imaging 2013;38:1033-1042. © 2013 Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)1033-1042
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Issue number5
StatePublished - Nov 1 2013


  • breast MRI
  • Dixon
  • dynamic contrast enhancement
  • fat suppression
  • view sharing

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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