Applications of endoscopic ultrasound in pancreatic cancer

Leticia Perondi Luz, Mohammad Ali Al-Haddad, Michael Sai Lai Sey, John DeWitt

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Since the introduction of endoscopic ultrasound guided fine-needle aspiration (EUS-FNA), EUS has assumed a growing role in the diagnosis and management of pancreatic ductal adenocarcinoma (PDAC). The objective of this review is to discuss the various applications of EUS and EUS-FNA in PDAC. Initially, its use for detection, diagnosis and staging will be described. EUS and EUS-FNA are highly accurate modalities for detection and diagnosis of PDAC, this high accuracy, however, is decreased in specific situations particularly in the presence of chronic pancreatitis. Novel techniques such as contrast-enhanced EUS, elastography and analysis of DNA markers such as k-ras mutation analysis in FNA samples are in progress and might improve the accuracy of EUS in the detection of PDAC in this setting and will be addressed. EUS and EUS-FNA have recently evolved from a diagnostic to a therapeutic technique in the management of PDAC. Significant developments in therapeutic EUS have occurred including advances in celiac plexus interventions with direct injection of ganglia and improved pain control, EUS-guided fiducial and brachytherapy seed placement, fine-needle injection of intra-tumoral agents and advances in EUS-guided biliary drainage. The future role of EUS and EUS in management of PDAC is still emerging.

Original languageEnglish
Pages (from-to)7808-7818
Number of pages11
JournalWorld Journal of Gastroenterology
Volume20
Issue number24
DOIs
StatePublished - 2014

Fingerprint

Pancreatic Neoplasms
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Adenocarcinoma
Celiac Plexus
Elasticity Imaging Techniques
Injections
Brachytherapy
Chronic Pancreatitis
Genetic Markers
Ganglia
Needles
Drainage
Seeds
Pain
Mutation
Therapeutics

Keywords

  • Endoscopic ultrasound guided fine-needle aspiration
  • Endoscopic ultrasound-guided fine needle aspiration
  • Endosonography
  • Pancreatic ductal carcinoma
  • Pancreatic neoplasm

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

Applications of endoscopic ultrasound in pancreatic cancer. / Luz, Leticia Perondi; Al-Haddad, Mohammad Ali; Sey, Michael Sai Lai; DeWitt, John.

In: World Journal of Gastroenterology, Vol. 20, No. 24, 2014, p. 7808-7818.

Research output: Contribution to journalArticle

Luz, Leticia Perondi ; Al-Haddad, Mohammad Ali ; Sey, Michael Sai Lai ; DeWitt, John. / Applications of endoscopic ultrasound in pancreatic cancer. In: World Journal of Gastroenterology. 2014 ; Vol. 20, No. 24. pp. 7808-7818.
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