Applied proteomics in breast cancer

Xianyin Lai, Sunil Badve

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Breast cancer is the most commonly diagnosed cancer and remains the second most common cause of cancer-related deaths in women. Proteomics has been used in biomedical research for 20 years. However, the application of proteomics in breast cancer remains a small fraction of breast cancer research. Comprehensive analysis of proteins is seldom used in clinical practice. Analysis of single proteins still remains the standard practice in clinical laboratories. Despite the use of multiplex methods for protein analysis in preclinical research, it is challenging to apply these techniques in the clinical setting. In this review, we summarize the commonly implemented array-based and mass spectrometry-based proteomic techniques, and the application of biomarkers for a specific purpose or mechanisms involved in breast cancer biology. The ultimate goal of this review is to help clinicians and scientists for choosing the right techniques and understanding their potential with respect to prognosis and prediction of the treatment outcome.

Original languageEnglish (US)
Title of host publicationMolecular Pathology of Breast Cancer
PublisherSpringer International Publishing
Pages403-414
Number of pages12
ISBN (Electronic)9783319417615
ISBN (Print)9783319417592
DOIs
StatePublished - Jan 1 2016

Keywords

  • Breast
  • Cancer
  • Proteomics

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Lai, X., & Badve, S. (2016). Applied proteomics in breast cancer. In Molecular Pathology of Breast Cancer (pp. 403-414). Springer International Publishing. https://doi.org/10.1007/978-3-319-41761-5_25