Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.

Original languageEnglish (US)
Article number163
JournalCommunications Biology
Volume1
Issue number1
DOIs
StatePublished - Dec 1 2018

Fingerprint

behavior disorders
Major Depressive Disorder
Bipolar Disorder
Psychiatry
Pedigree
pedigree
Inborn Genetic Diseases
assortative mating
Pathology
emotions
Mood Disorders
Joints
Observation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Medicine (miscellaneous)

Cite this

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder. / Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium.

In: Communications Biology, Vol. 1, No. 1, 163, 01.12.2018.

Research output: Contribution to journalArticle

Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium 2018, 'Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder', Communications Biology, vol. 1, no. 1, 163. https://doi.org/10.1038/s42003-018-0155-y
Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium. Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder. Communications Biology. 2018 Dec 1;1(1). 163. https://doi.org/10.1038/s42003-018-0155-y
Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium. / Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder. In: Communications Biology. 2018 ; Vol. 1, No. 1.
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