Approach to acute renal failure with multiple myeloma: Role of plasmapheresis

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14 Citations (Scopus)

Abstract

Multiple myeloma is commonly complicated by renal failure, which limits therapeutic options and aggravates the prognosis. In myeloma the most common cause of advanced renal failure is myeloma kidney, where light chains produced by tumor cells precipitate and impede kidney function. We suggest that plasma exchange is an appropriate intervention in advanced renal failure from multiple myeloma, and support this notion with two case reports. The two elderly individuals had advanced chronic and acute renal failure, and recovered after the removal of large quantities of light chains by existing membrane separation techniques. We also present an algorithm to approach renal failure and myeloma.

Original languageEnglish
Pages (from-to)417-422
Number of pages6
JournalTherapeutic Apheresis and Dialysis
Volume9
Issue number5
DOIs
StatePublished - Oct 2005

Fingerprint

Plasmapheresis
Multiple Myeloma
Acute Kidney Injury
Renal Insufficiency
Kidney
Light
Plasma Exchange
Chronic Kidney Failure
Membranes
Neoplasms
Therapeutics

Keywords

  • Light chains
  • Multiple myeloma
  • Plasmapheresis
  • Renal failure

ASJC Scopus subject areas

  • Hematology
  • Nephrology

Cite this

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abstract = "Multiple myeloma is commonly complicated by renal failure, which limits therapeutic options and aggravates the prognosis. In myeloma the most common cause of advanced renal failure is myeloma kidney, where light chains produced by tumor cells precipitate and impede kidney function. We suggest that plasma exchange is an appropriate intervention in advanced renal failure from multiple myeloma, and support this notion with two case reports. The two elderly individuals had advanced chronic and acute renal failure, and recovered after the removal of large quantities of light chains by existing membrane separation techniques. We also present an algorithm to approach renal failure and myeloma.",
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AU - Sharfuddin, Asif

AU - Dominguez, Jesus

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AB - Multiple myeloma is commonly complicated by renal failure, which limits therapeutic options and aggravates the prognosis. In myeloma the most common cause of advanced renal failure is myeloma kidney, where light chains produced by tumor cells precipitate and impede kidney function. We suggest that plasma exchange is an appropriate intervention in advanced renal failure from multiple myeloma, and support this notion with two case reports. The two elderly individuals had advanced chronic and acute renal failure, and recovered after the removal of large quantities of light chains by existing membrane separation techniques. We also present an algorithm to approach renal failure and myeloma.

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KW - Renal failure

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