Approach to Assessment of Parkinson Disease with Emphasis on Genetic Testing

Katelyn Payne, Brooke Walls, Joanne Wojcieszek

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

This article presents a nongeneticist's guide to understanding the genetics of Parkinson disease (PD), including clinical diagnostic criteria, differential diagnoses, symptom management, when to suspect a hereditary factor, a summary of autosomal dominant and recessive PD genes, and proposed algorithm for genetic testing. There is increasing availability of genetic testing for PD but there are few recommendations on how these tests should be used in clinical practice. This article guides clinicians on the overall management of patients with PD, with emphasis on determining which patients should have genetic testing and how to interpret the results.

Original languageEnglish (US)
JournalMedical Clinics of North America
DOIs
StateAccepted/In press - Jan 1 2019

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Keywords

  • GBA
  • Gene testing
  • Genetics
  • LRRK2
  • Parkinson disease
  • SNCA

ASJC Scopus subject areas

  • Medicine(all)

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