Approach to the hypophosphatemic patient

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Hypophosphatemia is commonly missed due to nonspecific signs and symptoms, but it causes considerable morbidity and in some cases contributes to mortality. Three primary mechanisms of hypophosphatemia exist: increased renal excretion, decreased intestinal absorption, and shifts from the extracellular to intracellular compartments. Renal hypophosphatemia can be further divided into fibroblast growth factor 23-mediated or non-fibroblast growth factor 23-mediated causes. Proper diagnosis requires a thorough medication history, family history, physical examination, and assessment of renal tubular phosphate handling to identify the cause. During the past decade, our understanding of phosphate metabolism has grown greatly through the study of rare disorders of phosphate homeostasis. Treatment of hypophosphatemia depends on the underlying disorder and requires close biochemical monitoring. This article illustrates an approach to the hypophosphatemic patient and discusses normal phosphate metabolism.

Original languageEnglish
Pages (from-to)696-706
Number of pages11
JournalJournal of Clinical Endocrinology and Metabolism
Volume97
Issue number3
DOIs
StatePublished - Mar 2012

Fingerprint

Hypophosphatemia
Phosphates
Metabolism
Kidney
Intestinal Absorption
Signs and Symptoms
Physical Examination
Intercellular Signaling Peptides and Proteins
Homeostasis
Morbidity
Mortality
Monitoring

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Approach to the hypophosphatemic patient. / Imel, Erik; Econs, Michael.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 97, No. 3, 03.2012, p. 696-706.

Research output: Contribution to journalArticle

@article{1982e5b291b44704bc03d8f16fdcdb8c,
title = "Approach to the hypophosphatemic patient",
abstract = "Hypophosphatemia is commonly missed due to nonspecific signs and symptoms, but it causes considerable morbidity and in some cases contributes to mortality. Three primary mechanisms of hypophosphatemia exist: increased renal excretion, decreased intestinal absorption, and shifts from the extracellular to intracellular compartments. Renal hypophosphatemia can be further divided into fibroblast growth factor 23-mediated or non-fibroblast growth factor 23-mediated causes. Proper diagnosis requires a thorough medication history, family history, physical examination, and assessment of renal tubular phosphate handling to identify the cause. During the past decade, our understanding of phosphate metabolism has grown greatly through the study of rare disorders of phosphate homeostasis. Treatment of hypophosphatemia depends on the underlying disorder and requires close biochemical monitoring. This article illustrates an approach to the hypophosphatemic patient and discusses normal phosphate metabolism.",
author = "Erik Imel and Michael Econs",
year = "2012",
month = "3",
doi = "10.1210/jc.2011-1319",
language = "English",
volume = "97",
pages = "696--706",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "3",

}

TY - JOUR

T1 - Approach to the hypophosphatemic patient

AU - Imel, Erik

AU - Econs, Michael

PY - 2012/3

Y1 - 2012/3

N2 - Hypophosphatemia is commonly missed due to nonspecific signs and symptoms, but it causes considerable morbidity and in some cases contributes to mortality. Three primary mechanisms of hypophosphatemia exist: increased renal excretion, decreased intestinal absorption, and shifts from the extracellular to intracellular compartments. Renal hypophosphatemia can be further divided into fibroblast growth factor 23-mediated or non-fibroblast growth factor 23-mediated causes. Proper diagnosis requires a thorough medication history, family history, physical examination, and assessment of renal tubular phosphate handling to identify the cause. During the past decade, our understanding of phosphate metabolism has grown greatly through the study of rare disorders of phosphate homeostasis. Treatment of hypophosphatemia depends on the underlying disorder and requires close biochemical monitoring. This article illustrates an approach to the hypophosphatemic patient and discusses normal phosphate metabolism.

AB - Hypophosphatemia is commonly missed due to nonspecific signs and symptoms, but it causes considerable morbidity and in some cases contributes to mortality. Three primary mechanisms of hypophosphatemia exist: increased renal excretion, decreased intestinal absorption, and shifts from the extracellular to intracellular compartments. Renal hypophosphatemia can be further divided into fibroblast growth factor 23-mediated or non-fibroblast growth factor 23-mediated causes. Proper diagnosis requires a thorough medication history, family history, physical examination, and assessment of renal tubular phosphate handling to identify the cause. During the past decade, our understanding of phosphate metabolism has grown greatly through the study of rare disorders of phosphate homeostasis. Treatment of hypophosphatemia depends on the underlying disorder and requires close biochemical monitoring. This article illustrates an approach to the hypophosphatemic patient and discusses normal phosphate metabolism.

UR - http://www.scopus.com/inward/record.url?scp=84858042043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858042043&partnerID=8YFLogxK

U2 - 10.1210/jc.2011-1319

DO - 10.1210/jc.2011-1319

M3 - Article

C2 - 22392950

AN - SCOPUS:84858042043

VL - 97

SP - 696

EP - 706

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 3

ER -