Approach to wild-type gastrointestinal stromal tumors

Joshua K. Kays, Jeffrey D. Sohn, Bradford J. Kim, Katherine Goze, Leonidas Koniaris

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Gastrointestinal stromal tumors (GISTs) arise from the intestinal pacemaker cells of Cajal. Wild-type gastrointestinal stromal tumors (WT-GIST) are a unique and uncommon subtype of GISTs that lack activating mutations in the tyrosine kinase c-KIT or platelet derived growth factor receptor alpha (PDGFRA) receptors. The lack of these growth-stimulating mutations renders tyrosine kinase receptor inhibitors, such as imatinib mesylate, relatively ineffective against these tumors. WT-GIST arises most commonly due to underlying alternate proliferative signals associated with germ-line, genetic mutations. WT-GIST frequently arises in patients with BRAF mutations, Carney's Triad or neurofibromatosis type-1 (NF-1). All patients with WT-GIST require a careful examination for germ-line mutations and very close observation for recurrent tumors. Surgery remains a mainstay therapy for these patients. This review aims to discuss the most recent data available on the diagnosis and treatment of WT-GIST.

Original languageEnglish (US)
Article number92
JournalTranslational Gastroenterology and Hepatology
Volume3
Issue numberNovember
DOIs
StatePublished - Nov 1 2018

Fingerprint

Gastrointestinal Stromal Tumors
Germ-Line Mutation
Mutation
Platelet-Derived Growth Factor alpha Receptor
Neurofibromatosis 1
Receptor Protein-Tyrosine Kinases
Protein-Tyrosine Kinases
Neoplasms
Observation
Therapeutics
Growth

Keywords

  • Gastrointestinal stromal tumor (GIST)
  • Sarcoma
  • Succinate dehydrogenase (SDH)
  • Wild-type gastrointestinal stromal tumor (WT-GIST)

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Approach to wild-type gastrointestinal stromal tumors. / Kays, Joshua K.; Sohn, Jeffrey D.; Kim, Bradford J.; Goze, Katherine; Koniaris, Leonidas.

In: Translational Gastroenterology and Hepatology, Vol. 3, No. November, 92, 01.11.2018.

Research output: Contribution to journalReview article

Kays, Joshua K. ; Sohn, Jeffrey D. ; Kim, Bradford J. ; Goze, Katherine ; Koniaris, Leonidas. / Approach to wild-type gastrointestinal stromal tumors. In: Translational Gastroenterology and Hepatology. 2018 ; Vol. 3, No. November.
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