Approach to wild-type gastrointestinal stromal tumors

Joshua K. Kays, Jeffrey D. Sohn, Bradford J. Kim, Katherine Goze, Leonidas Koniaris

Research output: Contribution to journalReview article

3 Scopus citations


Gastrointestinal stromal tumors (GISTs) arise from the intestinal pacemaker cells of Cajal. Wild-type gastrointestinal stromal tumors (WT-GIST) are a unique and uncommon subtype of GISTs that lack activating mutations in the tyrosine kinase c-KIT or platelet derived growth factor receptor alpha (PDGFRA) receptors. The lack of these growth-stimulating mutations renders tyrosine kinase receptor inhibitors, such as imatinib mesylate, relatively ineffective against these tumors. WT-GIST arises most commonly due to underlying alternate proliferative signals associated with germ-line, genetic mutations. WT-GIST frequently arises in patients with BRAF mutations, Carney's Triad or neurofibromatosis type-1 (NF-1). All patients with WT-GIST require a careful examination for germ-line mutations and very close observation for recurrent tumors. Surgery remains a mainstay therapy for these patients. This review aims to discuss the most recent data available on the diagnosis and treatment of WT-GIST.

Original languageEnglish (US)
Article number92
JournalTranslational Gastroenterology and Hepatology
Issue numberNovember
StatePublished - Nov 1 2018


  • Gastrointestinal stromal tumor (GIST)
  • Sarcoma
  • Succinate dehydrogenase (SDH)
  • Wild-type gastrointestinal stromal tumor (WT-GIST)

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Approach to wild-type gastrointestinal stromal tumors'. Together they form a unique fingerprint.

  • Cite this