Apurinic/apyrimidinic endonuclease expression in pediatric yolk sac tumors

B. G. Thomson, R. Tritt, M. Davis, E. J. Perlman, Mark Kelley

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The enzyme apurinic/apyriminidic endonuclease/redox factor 1 (Ape1/ref1), a key protein in the base excision repair pathway, displays repair and redox activity. We examined the role of Ape1/ref1 and a protein it regulates, hypoxia inducible factor 1 alpha (HIF-1α) in pediatric yolk sac tumors. Patients and Methods: Using an immunohistochemical evaluation, 16 pediatric yolk sac tumors were evaluated for Ape1/ref1 and HIF-1α expression. Samples were obtained from archival tissue. Results: We demonstrated high levels of expression of Ape1/ref1 in 14/16 of the tumors. This expression was limited to the nucleus of the viable portion of each tumor. High levels of HIF-1α expression was noted in half of the same tumors and localized to both the nucleus and cytoplasm of the viable tumor. Conclusions: The high levels of expression of Ape1/ref1 in this group of chemosensitive tumors may be related to the subcellular location or redox regulatory activity of one of the other factors controlled by Ape1/ref1.

Original languageEnglish
Pages (from-to)4153-4157
Number of pages5
JournalAnticancer Research
Volume20
Issue number6 B
StatePublished - 2000

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DNA-(Apurinic or Apyrimidinic Site) Lyase
Endodermal Sinus Tumor
Hypoxia-Inducible Factor 1
Pediatrics
Oxidation-Reduction
Neoplasms
DNA Repair
Cytoplasm
Proteins
Enzymes

Keywords

  • DNA repair
  • Germ cell tumor
  • Redox

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Thomson, B. G., Tritt, R., Davis, M., Perlman, E. J., & Kelley, M. (2000). Apurinic/apyrimidinic endonuclease expression in pediatric yolk sac tumors. Anticancer Research, 20(6 B), 4153-4157.

Apurinic/apyrimidinic endonuclease expression in pediatric yolk sac tumors. / Thomson, B. G.; Tritt, R.; Davis, M.; Perlman, E. J.; Kelley, Mark.

In: Anticancer Research, Vol. 20, No. 6 B, 2000, p. 4153-4157.

Research output: Contribution to journalArticle

Thomson, BG, Tritt, R, Davis, M, Perlman, EJ & Kelley, M 2000, 'Apurinic/apyrimidinic endonuclease expression in pediatric yolk sac tumors', Anticancer Research, vol. 20, no. 6 B, pp. 4153-4157.
Thomson BG, Tritt R, Davis M, Perlman EJ, Kelley M. Apurinic/apyrimidinic endonuclease expression in pediatric yolk sac tumors. Anticancer Research. 2000;20(6 B):4153-4157.
Thomson, B. G. ; Tritt, R. ; Davis, M. ; Perlman, E. J. ; Kelley, Mark. / Apurinic/apyrimidinic endonuclease expression in pediatric yolk sac tumors. In: Anticancer Research. 2000 ; Vol. 20, No. 6 B. pp. 4153-4157.
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