Aripiprazole for irritability associated with autistic disorder in children and adolescents aged 6-17 years

Kelly Blankenship, Craig A. Erickson, Kimberly A. Stigler, David J. Posey, Christopher J. McDougle

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Aripiprazole was recently US FDA-approved to treat irritability in children and adolescents with autistic disorder aged 6-17 years. There are currently only two psychotropics approved by the FDA to treat irritability in the autistic population. This drug profile will discuss available studies of aripiprazole in individuals with pervasive developmental disorders, two of which led to its recent FDA approval. We will discuss the efficacy, as well as the safety and tolerability of the drug documented in these studies. In addition, the chemistry, pharmacokinetics, metabolism and mechanism of action of aripiprazole will be reviewed.

Original languageEnglish (US)
Pages (from-to)375-381
Number of pages7
JournalPediatric Health
Volume4
Issue number4
DOIs
StatePublished - Aug 1 2010

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Keywords

  • aripiprazole
  • Aspergers disorder
  • autistic disorder
  • dehyro-aripiprazole
  • pervasive developmental disorder
  • pervasive developmental disorder not otherwise specified
  • quinolinone antipsychotic

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pediatrics

Cite this

Blankenship, K., Erickson, C. A., Stigler, K. A., Posey, D. J., & McDougle, C. J. (2010). Aripiprazole for irritability associated with autistic disorder in children and adolescents aged 6-17 years. Pediatric Health, 4(4), 375-381. https://doi.org/10.2217/phe.10.45