Arterial aging and arterial disease: Interplay between central hemodynamics, cardiac work, and organ flow-implications for CKD and cardiovascular disease

Gerard London, Adrian Covic, David Goldsmith, Andrzej Wiecek, Gultekin Suleymanlar, Alberto Ortiz, Ziad Massy, Bengt Lindholm, Alberto Martinez-Castelao, Danilo Fliser, Rajiv Agarwal, Kitty J. Jager, Friedo W. Dekker, Peter J. Blankestijn, Carmine Zoccali

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Cardiovascular disease is an important cause of morbidity and mortality in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). All epidemiological studies have clearly shown that accelerated arterial and cardiac aging is characteristic of these populations. Arterial premature aging is heterogeneous. It principally involves the aorta and central capacitive arteries, and is characterized by preferential aortic stiffening and disappearance of stiffness/impedance gradients between the central and peripheral arteries. These changes have a double impact: on the heart, upstream, with left ventricular hypertrophy and decreased coronary perfusion; and, downstream, on renal and brain microcirculation (decrease in glomerular filtration and cognitive functions). Multifactorial at origin, the pathophysiology of aortic 'progeria' and microvascular disorders in CKD/ESRD is not well understood and should be the focus of interest in future studies.

Original languageEnglish (US)
Pages (from-to)10-12
Number of pages3
JournalKidney International Supplements
Volume1
Issue number1
DOIs
StatePublished - Jun 1 2011

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Keywords

  • aging
  • arterial stiffness
  • arteriosclerosis
  • end-stage renal disease
  • pressure waves

ASJC Scopus subject areas

  • Nephrology

Cite this

London, G., Covic, A., Goldsmith, D., Wiecek, A., Suleymanlar, G., Ortiz, A., Massy, Z., Lindholm, B., Martinez-Castelao, A., Fliser, D., Agarwal, R., Jager, K. J., Dekker, F. W., Blankestijn, P. J., & Zoccali, C. (2011). Arterial aging and arterial disease: Interplay between central hemodynamics, cardiac work, and organ flow-implications for CKD and cardiovascular disease. Kidney International Supplements, 1(1), 10-12. https://doi.org/10.1038/kisup.2011.5