Arterial thromboembolism in cancer patients treated with cisplatin: A systematic review and meta-analysis

Tracy Proverbs-Singh, Sophia K. Chiu, Ziyue Liu, Sonia Seng, Guru Sonpavde, Toni K. Choueiri, Che Kai Tsao, Menggang Yu, Noah M. Hahn, William K. Oh, Matthew D. Galsky

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Cisplatin has been associated with an increased risk of arterial thromboembolic events (ATEs). However, because this association is mostly based on case reports and retrospective studies, we conducted a systemic review and meta-analysis of randomized controlled trials evaluating the incidence and risk of ATEs associated with cisplatin. Eligible studies included prospective randomized phase II and III trials evaluating cisplatin-based vs non-cisplatin-based chemotherapy in patients with solid tumors, which were identified from PubMed articles published between 1990 and 2010. Incidence rates, relative risks (RRs), and 95% confidence intervals (CIs) were calculated using a random effects model. A total of 8216 patients from 38 trials were included. Among patients treated with cisplatin-based chemotherapy, the summary incidence of ATEs was 0.67% (95% CI 0.40% to 0.95%), and the RR of ATEs was 1.36 (95% CI 0.86 to 2.17; P .19). No increase in ATEs was detected in any prespecified subgroup.

Original languageEnglish (US)
Pages (from-to)1837-1840
Number of pages4
JournalJournal of the National Cancer Institute
Volume104
Issue number23
DOIs
StatePublished - Dec 2012
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Proverbs-Singh, T., Chiu, S. K., Liu, Z., Seng, S., Sonpavde, G., Choueiri, T. K., Tsao, C. K., Yu, M., Hahn, N. M., Oh, W. K., & Galsky, M. D. (2012). Arterial thromboembolism in cancer patients treated with cisplatin: A systematic review and meta-analysis. Journal of the National Cancer Institute, 104(23), 1837-1840. https://doi.org/10.1093/jnci/djs435