Arteriovenous fistulas as adjuncts to venous bypass grafts

Stephen G. Lalka, Joseph L. Unthank, John G. Mcgue, Dolores F. Cikrit, Alan Sawchuk, Michael Dalsing

Research output: Contribution to journalArticle

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Abstract

A canine model of occlusive hindlimb venous hypertension was used to determine which of two different, clinically applicable, adjunctive arteriovenous fistulas (A VFs), sequential or peripheral, would augment flow in autogenous cross- femoral venous bypass grafts (CFBs) with the least alteration of hindlimb hemodynamics. Unilateral venous hypertension was produced by iliofemoral venous ligation in three groups of five dogs: group I, venous ligation only (controls); group II, venous ligation followed by CFB with a sequential A VF; and group III, venous ligation with CFB and peripheral A VF. Bilateral hindlimb venous and arterial pressures and flows, and graft flows, were measured preoperatively and for 4 h postoperatively. Insertion of a CFB eliminated the venous hypertension in all 10 bypass dogs. Graft flow was augmented by addition of the sequential AVF (to 1167 ± 309 mL/minfrom 92 ± 12.3 mL/min: p > 0001). However, this was accompanied, both in the limb ipsilateral to the AVF and in the contralateral limb, by the return of significant venous hypertension (p > 001) and significant reduction (even reversal) of femoral vein flow caudad to the CFB (p > 005). In contrast, adding the peripheral AVF augmented graft flow (to 200 ± 62 mL/minfrom 65 ± 43.7 mL/min; p > 0001), but did not elevate venous pressure or impair venous flow in either hindlimb. The data from this short-term canine model suggest that a peripheral adjunctive AVF may effectively augment CFB graft flow without the potential for detrimental effects on venous hemodynamics characteristic of the sequential AVF

Original languageEnglish
Pages (from-to)125-136
Number of pages12
JournalJournal of Investigative Surgery
Volume4
Issue number2
DOIs
StatePublished - 1991

Fingerprint

Arteriovenous Fistula
Hindlimb
Ligation
Transplants
Hypertension
Venous Pressure
Canidae
Extremities
Hemodynamics
Dogs
Femoral Vein
Thigh
Arterial Pressure

Keywords

  • Arteriovenous fistulas
  • Venous grafts

ASJC Scopus subject areas

  • Surgery

Cite this

Arteriovenous fistulas as adjuncts to venous bypass grafts. / Lalka, Stephen G.; Unthank, Joseph L.; Mcgue, John G.; Cikrit, Dolores F.; Sawchuk, Alan; Dalsing, Michael.

In: Journal of Investigative Surgery, Vol. 4, No. 2, 1991, p. 125-136.

Research output: Contribution to journalArticle

Lalka, Stephen G. ; Unthank, Joseph L. ; Mcgue, John G. ; Cikrit, Dolores F. ; Sawchuk, Alan ; Dalsing, Michael. / Arteriovenous fistulas as adjuncts to venous bypass grafts. In: Journal of Investigative Surgery. 1991 ; Vol. 4, No. 2. pp. 125-136.
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