Arylsulfonate esters as hypocholesteremic agents: III. Mechanism of action studies

J. E. MacNintch, R. A. Harris, W. McLean Grogan, C. L. Villemez, F. W. Quackenbush

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The mechanism responsible for the hypocholestermic action of arylsulfonate esters of long chain fatty alcohols has been studied with rats fed either normocholesteremic or hypercholesteremic (1% cholesterol plus 0.5% glycocholate) diets. Linoleyl tosylate is more effective in lowering plasma and liver cholesterol levels of rats on the hypercholesteremic diet than several other hypocholesteremic agents tested. Linoleyl tosylate does not redistribute cholesterol to extrahepatic tissues nor inhibit hepatic cholesterol biosynthesis. Linoleyl tosylate is not effective in counteracting Tritoninduced hypercholesteremia nor in lowering plasma cholesterol levels of the suckling rat. Linoleyl tosylate increases the fecal elimination of dietary [4-14C] cholesterol and prevents its accumulation in blood and liver. Oleyl p-(n-decyl) benzene sulfonate also prevents the apparent absorption of [26-14C] cholesterol from the gastrointestinal tract. Linoleyl tosylate increases the fecal excretion of neurtal sterols but not of bile acids. The results indicate that the arylsulfonate esters of long chain fatty alcohols lower body cholesterol levels by inhibiting cholesterol absorption from the gastrointestinal tract. Exactly how absorption is inhibited is not clear, but linoleyl tosylate was found to stimulate the activity of cholesteryl esterase prepared from the intestinal mucosa.

Original languageEnglish (US)
Pages (from-to)819-827
Number of pages9
JournalLipids
Volume12
Issue number10
DOIs
StatePublished - Oct 1 1977
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

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    MacNintch, J. E., Harris, R. A., McLean Grogan, W., Villemez, C. L., & Quackenbush, F. W. (1977). Arylsulfonate esters as hypocholesteremic agents: III. Mechanism of action studies. Lipids, 12(10), 819-827. https://doi.org/10.1007/BF02533271