Arylsulfonate esters as hypocholesteremic agents

III. Mechanism of action studies

J. E. MacNintch, Robert Harris, W. McLean Grogan, C. L. Villemez, F. W. Quackenbush

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The mechanism responsible for the hypocholestermic action of arylsulfonate esters of long chain fatty alcohols has been studied with rats fed either normocholesteremic or hypercholesteremic (1% cholesterol plus 0.5% glycocholate) diets. Linoleyl tosylate is more effective in lowering plasma and liver cholesterol levels of rats on the hypercholesteremic diet than several other hypocholesteremic agents tested. Linoleyl tosylate does not redistribute cholesterol to extrahepatic tissues nor inhibit hepatic cholesterol biosynthesis. Linoleyl tosylate is not effective in counteracting Tritoninduced hypercholesteremia nor in lowering plasma cholesterol levels of the suckling rat. Linoleyl tosylate increases the fecal elimination of dietary [4-14C] cholesterol and prevents its accumulation in blood and liver. Oleyl p-(n-decyl) benzene sulfonate also prevents the apparent absorption of [26-14C] cholesterol from the gastrointestinal tract. Linoleyl tosylate increases the fecal excretion of neurtal sterols but not of bile acids. The results indicate that the arylsulfonate esters of long chain fatty alcohols lower body cholesterol levels by inhibiting cholesterol absorption from the gastrointestinal tract. Exactly how absorption is inhibited is not clear, but linoleyl tosylate was found to stimulate the activity of cholesteryl esterase prepared from the intestinal mucosa.

Original languageEnglish (US)
Pages (from-to)819-827
Number of pages9
JournalLipids
Volume12
Issue number10
DOIs
StatePublished - Oct 1977
Externally publishedYes

Fingerprint

Arylsulfonates
Anticholesteremic Agents
mechanism of action
Esters
esters
Cholesterol
cholesterol
Fatty Alcohols
Rats
fatty alcohols
Nutrition
Liver
liver
gastrointestinal system
Gastrointestinal Tract
rats
Glycocholic Acid
Diet
Plasmas
anticholesteremic agents

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Food Science
  • Organic Chemistry
  • Cell Biology

Cite this

MacNintch, J. E., Harris, R., McLean Grogan, W., Villemez, C. L., & Quackenbush, F. W. (1977). Arylsulfonate esters as hypocholesteremic agents: III. Mechanism of action studies. Lipids, 12(10), 819-827. https://doi.org/10.1007/BF02533271

Arylsulfonate esters as hypocholesteremic agents : III. Mechanism of action studies. / MacNintch, J. E.; Harris, Robert; McLean Grogan, W.; Villemez, C. L.; Quackenbush, F. W.

In: Lipids, Vol. 12, No. 10, 10.1977, p. 819-827.

Research output: Contribution to journalArticle

MacNintch, JE, Harris, R, McLean Grogan, W, Villemez, CL & Quackenbush, FW 1977, 'Arylsulfonate esters as hypocholesteremic agents: III. Mechanism of action studies', Lipids, vol. 12, no. 10, pp. 819-827. https://doi.org/10.1007/BF02533271
MacNintch JE, Harris R, McLean Grogan W, Villemez CL, Quackenbush FW. Arylsulfonate esters as hypocholesteremic agents: III. Mechanism of action studies. Lipids. 1977 Oct;12(10):819-827. https://doi.org/10.1007/BF02533271
MacNintch, J. E. ; Harris, Robert ; McLean Grogan, W. ; Villemez, C. L. ; Quackenbush, F. W. / Arylsulfonate esters as hypocholesteremic agents : III. Mechanism of action studies. In: Lipids. 1977 ; Vol. 12, No. 10. pp. 819-827.
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