Asparagine, a critical limiting metabolite during glutamine starvation

Jie Jiang, Natalya N. Pavlova, Ji Zhang

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

A challenge of targeting glutamine metabolism in cancer is that tumor cells develop various strategies to adapt to glutamine limitation. We found that asparagine plays a critical role in supporting protein synthesis during glutamine starvation, highlighting a possible approach to optimize the therapeutic efficacy of targeting glutamine metabolism in cancer.

Original languageEnglish (US)
Article numbere1441633
JournalMolecular and Cellular Oncology
Volume5
Issue number3
DOIs
StatePublished - May 4 2018

Keywords

  • asparaginase
  • asparagine
  • biology of malignant cells
  • glutamine
  • glutamine synthetase
  • mechanisms of oncogenesis and tumor progression
  • novel therapeutic targets
  • oncogenes and tumor suppressor genes
  • protein synthesis
  • tumor metabolism

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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