Assessing breast tumor margin by multispectral photoacoustic tomography

Rui Li, Pu Wang, Lu Lan, Frank P. Lloyd, Craig J. Goergen, Shaoxiong Chen, Ji Xin Cheng

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

An unmet need exists in high-speed and highly-sensitive intraoperative assessment of breast cancer margin during conservation surgical procedures. Here, we demonstrate a multispectral photoacoustic tomography system for breast tumor margin assessment using fat and hemoglobin as contrasts. This system provides ~3 mm tissue depth and ~125 μm axial resolution. The results agreed with the histological findings. A high sensitivity in margin assessment was accomplished, which opens a compelling way to intraoperative margin assessment.

Original languageEnglish (US)
Article numberA015
Pages (from-to)1273-1281
Number of pages9
JournalBiomedical Optics Express
Volume6
Issue number4
DOIs
StatePublished - Mar 12 2015

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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  • Cite this

    Li, R., Wang, P., Lan, L., Lloyd, F. P., Goergen, C. J., Chen, S., & Cheng, J. X. (2015). Assessing breast tumor margin by multispectral photoacoustic tomography. Biomedical Optics Express, 6(4), 1273-1281. [A015]. https://doi.org/10.1364/BOE.6.001273