Assessing breast tumor margin by multispectral photoacoustic tomography

Rui Li, Pu Wang, Lu Lan, Frank P. Lloyd, Craig J. Goergen, Shaoxiong Chen, Ji Xin Cheng

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

An unmet need exists in high-speed and highly-sensitive intraoperative assessment of breast cancer margin during conservation surgical procedures. Here, we demonstrate a multispectral photoacoustic tomography system for breast tumor margin assessment using fat and hemoglobin as contrasts. This system provides ~3 mm tissue depth and ~125 μm axial resolution. The results agreed with the histological findings. A high sensitivity in margin assessment was accomplished, which opens a compelling way to intraoperative margin assessment.

Original languageEnglish (US)
Article numberA015
Pages (from-to)1273-1281
Number of pages9
JournalBiomedical Optics Express
Volume6
Issue number4
DOIs
StatePublished - Mar 12 2015

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breast
margins
tumors
tomography
Tomography
Breast Neoplasms
Hemoglobins
Fats
fats
hemoglobin
conservation
cancer
high speed
sensitivity

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Cite this

Li, R., Wang, P., Lan, L., Lloyd, F. P., Goergen, C. J., Chen, S., & Cheng, J. X. (2015). Assessing breast tumor margin by multispectral photoacoustic tomography. Biomedical Optics Express, 6(4), 1273-1281. [A015]. https://doi.org/10.1364/BOE.6.001273

Assessing breast tumor margin by multispectral photoacoustic tomography. / Li, Rui; Wang, Pu; Lan, Lu; Lloyd, Frank P.; Goergen, Craig J.; Chen, Shaoxiong; Cheng, Ji Xin.

In: Biomedical Optics Express, Vol. 6, No. 4, A015, 12.03.2015, p. 1273-1281.

Research output: Contribution to journalArticle

Li, R, Wang, P, Lan, L, Lloyd, FP, Goergen, CJ, Chen, S & Cheng, JX 2015, 'Assessing breast tumor margin by multispectral photoacoustic tomography', Biomedical Optics Express, vol. 6, no. 4, A015, pp. 1273-1281. https://doi.org/10.1364/BOE.6.001273
Li, Rui ; Wang, Pu ; Lan, Lu ; Lloyd, Frank P. ; Goergen, Craig J. ; Chen, Shaoxiong ; Cheng, Ji Xin. / Assessing breast tumor margin by multispectral photoacoustic tomography. In: Biomedical Optics Express. 2015 ; Vol. 6, No. 4. pp. 1273-1281.
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