Assessing carotid atherosclerosis by fiber-optic multispectral photoacoustic tomography

Jie Hui, Rui Li, Pu Wang, Evan Phillips, Rebecca Bruning, Chien Sheng Liao, Michael Sturek, Craig J. Goergen, Ji Xin Cheng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Atherosclerotic plaque at the carotid bifurcation is the underlying cause of the majority of ischemic strokes. Noninvasive imaging and quantification of the compositional changes preceding gross anatomic changes within the arterial wall is essential for diagnosis of disease. Current imaging modalities such as duplex ultrasound, computed tomography, positron emission tomography are limited by the lack of compositional contrast and the detection of flow-limiting lesions. Although high-resolution magnetic resonance imaging has been developed to characterize atherosclerotic plaque composition, its accessibility for wide clinical use is limited. Here, we demonstrate a fiber-based multispectral photoacoustic tomography system for excitation of lipids and external acoustic detection of the generated ultrasound. Using sequential ultrasound imaging of ex vivo preparations we achieved ∼2 cm imaging depth and chemical selectivity for assessment of human arterial plaques. A multivariate curve resolution alternating least squares analysis method was applied to resolve the major chemical components, including intravascular lipid, intramuscular fat, and blood. These results show the promise of detecting carotid plaque in vivo through esophageal fiber-optic excitation of lipids and external acoustic detection of the generated ultrasound. This imaging system has great potential for serving as a point-of-care device for early diagnosis of carotid artery disease in the clinic.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2015
EditorsAlexander A. Oraevsky, Lihong V. Wang
PublisherSPIE
ISBN (Electronic)9781628414134
DOIs
StatePublished - Jan 1 2015
EventPhotons Plus Ultrasound: Imaging and Sensing 2015 - San Francisco, United States
Duration: Feb 8 2015Feb 10 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9323
ISSN (Print)1605-7422

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2015
CountryUnited States
CitySan Francisco
Period2/8/152/10/15

Fingerprint

arteriosclerosis
Carotid Artery Diseases
Photoacoustic effect
Fiber optics
sound detecting and ranging
Tomography
lipids
fiber optics
tomography
Atherosclerotic Plaques
Lipids
Imaging techniques
Acoustics
Ultrasonics
Point-of-Care Systems
fats
arteries
strokes
Least-Squares Analysis
lesions

Keywords

  • Carotid artery disease
  • Carotid atherosclerosis
  • Multispectral imaging
  • Multivariate curve resolution alternating least squares
  • Photoacoustic imaging
  • Ultrasound

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Hui, J., Li, R., Wang, P., Phillips, E., Bruning, R., Liao, C. S., ... Cheng, J. X. (2015). Assessing carotid atherosclerosis by fiber-optic multispectral photoacoustic tomography. In A. A. Oraevsky, & L. V. Wang (Eds.), Photons Plus Ultrasound: Imaging and Sensing 2015 [93233S] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9323). SPIE. https://doi.org/10.1117/12.2076999

Assessing carotid atherosclerosis by fiber-optic multispectral photoacoustic tomography. / Hui, Jie; Li, Rui; Wang, Pu; Phillips, Evan; Bruning, Rebecca; Liao, Chien Sheng; Sturek, Michael; Goergen, Craig J.; Cheng, Ji Xin.

Photons Plus Ultrasound: Imaging and Sensing 2015. ed. / Alexander A. Oraevsky; Lihong V. Wang. SPIE, 2015. 93233S (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9323).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hui, J, Li, R, Wang, P, Phillips, E, Bruning, R, Liao, CS, Sturek, M, Goergen, CJ & Cheng, JX 2015, Assessing carotid atherosclerosis by fiber-optic multispectral photoacoustic tomography. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2015., 93233S, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9323, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2015, San Francisco, United States, 2/8/15. https://doi.org/10.1117/12.2076999
Hui J, Li R, Wang P, Phillips E, Bruning R, Liao CS et al. Assessing carotid atherosclerosis by fiber-optic multispectral photoacoustic tomography. In Oraevsky AA, Wang LV, editors, Photons Plus Ultrasound: Imaging and Sensing 2015. SPIE. 2015. 93233S. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2076999
Hui, Jie ; Li, Rui ; Wang, Pu ; Phillips, Evan ; Bruning, Rebecca ; Liao, Chien Sheng ; Sturek, Michael ; Goergen, Craig J. ; Cheng, Ji Xin. / Assessing carotid atherosclerosis by fiber-optic multispectral photoacoustic tomography. Photons Plus Ultrasound: Imaging and Sensing 2015. editor / Alexander A. Oraevsky ; Lihong V. Wang. SPIE, 2015. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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