Assessing dopaminergic neurotransmission with pet: Basic theory and applications in alcohol research

Karmen Yoder, David Kareken, Evan D. Morris

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Over the last two decades, using PET imaging to assess changes in endogenous dopamine has become a standard neurochemical research technique. Initially, investigators focused on the in vivo study of direct pharmacological manipulation of the dopamine system (e.g., amphetamine, cocaine, methylphenidate). More recently, there has been a shift toward studying the role that dopamine plays in cognitive processes and in response to commonly used drugs with subtler effects on the dopamine system. Here, we outline the conceptual foundations of using PET to assess alterations in brain dopamine, and provide the reader with important theoretical constructs that must be addressed when designing such studies. Data from recent work with dopaminergic PET ligands are used to provide concrete examples of relevant design considerations.

Original languageEnglish
Pages (from-to)118-124
Number of pages7
JournalCurrent Medical Imaging Reviews
Volume7
Issue number2
DOIs
StatePublished - Jun 2011

Fingerprint

Pets
Synaptic Transmission
Dopamine
Alcohols
Research
Methylphenidate
Amphetamine
Cocaine
Research Design
Research Personnel
Pharmacology
Ligands
Brain
Pharmaceutical Preparations

Keywords

  • Dopamine d2 receptor
  • Dopamine release
  • Neurotransmitter
  • Position emission tomography
  • Tracer kinetic modeling

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Assessing dopaminergic neurotransmission with pet : Basic theory and applications in alcohol research. / Yoder, Karmen; Kareken, David; Morris, Evan D.

In: Current Medical Imaging Reviews, Vol. 7, No. 2, 06.2011, p. 118-124.

Research output: Contribution to journalArticle

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