Assessment of exhaled nitric oxide kinetics in healthy infants

T. Martínez, A. Weist, T. Williams, C. Clem, P. Silkoff, Robert Tepper

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Exhaled nitric oxide (FENO) measurements provide a noninvasive approach to the evaluation of airway inflammation. Flow-independent NO exchange parameters [airway NO transfer factor (DNO) and airway wall NO concentration (CwNO)] can be estimated from FENO measurements at low flows and may elucidate mechanisms of disturbances in NO exchange. We measured FENO in sedated infants by using an adaptation of a raised lung volume rapid thoracic compression technique that creates forced expiration through a mass-flow controller that lasts 5-10 s, at a constant preset flow. We measured FENO at expired flows of 50, 25, and 15 ml/s in five healthy infants (7-31 mo). Median FENO increased [24, 40, and 60 parts per billion (ppb)] with decreasing expiratory flows (50, 25, and 15 ml/s). Group median (range) for DNO and CwNO were 12.7 (3.2-37) × 10-3 nl·s-1·ppb-1 and 108.9 (49-385) ppb, respectively, similar to values reported in healthy adults. Exhaled NO is flow dependent; flow-independent parameters of exhaled NO kinetics can be assessed in infants and are similar to values described in adults.

Original languageEnglish
Pages (from-to)2384-2390
Number of pages7
JournalJournal of Applied Physiology
Volume94
Issue number6
StatePublished - Jun 1 2003

Fingerprint

Nitric Oxide
Transfer Factor
Thorax
Inflammation
Lung

Keywords

  • Airway inflammation
  • Lung function
  • Nitric oxide measurement

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Martínez, T., Weist, A., Williams, T., Clem, C., Silkoff, P., & Tepper, R. (2003). Assessment of exhaled nitric oxide kinetics in healthy infants. Journal of Applied Physiology, 94(6), 2384-2390.

Assessment of exhaled nitric oxide kinetics in healthy infants. / Martínez, T.; Weist, A.; Williams, T.; Clem, C.; Silkoff, P.; Tepper, Robert.

In: Journal of Applied Physiology, Vol. 94, No. 6, 01.06.2003, p. 2384-2390.

Research output: Contribution to journalArticle

Martínez, T, Weist, A, Williams, T, Clem, C, Silkoff, P & Tepper, R 2003, 'Assessment of exhaled nitric oxide kinetics in healthy infants', Journal of Applied Physiology, vol. 94, no. 6, pp. 2384-2390.
Martínez T, Weist A, Williams T, Clem C, Silkoff P, Tepper R. Assessment of exhaled nitric oxide kinetics in healthy infants. Journal of Applied Physiology. 2003 Jun 1;94(6):2384-2390.
Martínez, T. ; Weist, A. ; Williams, T. ; Clem, C. ; Silkoff, P. ; Tepper, Robert. / Assessment of exhaled nitric oxide kinetics in healthy infants. In: Journal of Applied Physiology. 2003 ; Vol. 94, No. 6. pp. 2384-2390.
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