Assessment of inhibited alveolar-capillary membrane structural development and function in bronchopulmonary dysplasia

Shawn K. Ahlfeld, Simon Conway

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Bronchopulmonary dysplasia (BPD) is a chronic lung disease of extreme prematurity and is defined clinically by dependence on supplemental oxygen due to impaired gas exchange. Optimal gas exchange is dependent on the development of a sufficient surface area for diffusion. In the mammalian lung, rapid acquisition of distal lung surface area is accomplished in neonatal and early adult life by means of vascularization and secondary septation of distal lung airspaces. Extreme preterm birth interrupts secondary septation and pulmonary capillary development and ultimately reduces the efficiency of the alveolar-capillary membrane. Although pulmonary health in BPD infants rapidly improves over the first few years, persistent alveolar-capillary membrane dysfunction continues into adolescence and adulthood. Preventative therapies have been largely ineffective, and therapies aimed at promoting normal development of the air-blood barrier in infants with established BPD remain largely unexplored. The purpose of this review will be: (1) to summarize the histological evidence of aberrant alveolar-capillary membrane development associated with extreme preterm birth and BPD, (2) to review the clinical evidence assessing the long-term impact of BPD on alveolar-capillary membrane function, and (3) to discuss the need to develop and incorporate direct measurements of functional gas exchange into clinically relevant animal models of inhibited alveolar development.

Original languageEnglish
Pages (from-to)168-179
Number of pages12
JournalBirth Defects Research Part A - Clinical and Molecular Teratology
Volume100
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Bronchopulmonary Dysplasia
Lung
Membranes
Gases
Premature Birth
Blood-Air Barrier
Lung Diseases
Chronic Disease
Animal Models
Oxygen
Health
Therapeutics

Keywords

  • Bronchopulmonary dysplasia
  • Diffusing capacity
  • Hyperoxia
  • Lung function
  • Mouse
  • Neonatal lung morphogenesis

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Medicine(all)

Cite this

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