Assessment of posterior fossa structures with midsagittal MRI

The effects of age

Sunjay A. Shah, P. Murali Doraiswamy, Mustafa M. Husain, Gary S. Figiel, Orest Boyko, William M. McDonald, Everett H. Ellinwood, K. Ranga Rama Krishnan

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Midsagittal magnetic resonance (MR) images of 36 normal volunteers, ranging in age from 26 to 79 years, were used to evaluate the effects of age on the size of posterior fossa structures (cerebellar vermis, midbrain, pons, medulla and fourth ventricle). Our results demonstrate a highly statistically significant age-related decline in the cross-sectional area of the midbrain (r = -.44, p<0.007), a less prominent decline in the area of the anterior cerebellar vermis (r = -.33, p<0.05) and striking intercorrelations between the dimensions of the pons, medulla and cerebellar vermis. To the best of our knowledge, this is the first MRI demonstration of midbrain atrophy during aging in normal adults.

Original languageEnglish (US)
Pages (from-to)371-374
Number of pages4
JournalNeurobiology of Aging
Volume12
Issue number4
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Mesencephalon
Pons
Fourth Ventricle
Atrophy
Healthy Volunteers
Magnetic Resonance Spectroscopy
Cerebellar Vermis

Keywords

  • Cerebellar vermis
  • Fourth ventricle
  • Magnetic resonance
  • Medulla
  • Midbrain
  • Pons

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

Shah, S. A., Doraiswamy, P. M., Husain, M. M., Figiel, G. S., Boyko, O., McDonald, W. M., ... Ranga Rama Krishnan, K. (1991). Assessment of posterior fossa structures with midsagittal MRI: The effects of age. Neurobiology of Aging, 12(4), 371-374. https://doi.org/10.1016/0197-4580(91)90025-F

Assessment of posterior fossa structures with midsagittal MRI : The effects of age. / Shah, Sunjay A.; Doraiswamy, P. Murali; Husain, Mustafa M.; Figiel, Gary S.; Boyko, Orest; McDonald, William M.; Ellinwood, Everett H.; Ranga Rama Krishnan, K.

In: Neurobiology of Aging, Vol. 12, No. 4, 1991, p. 371-374.

Research output: Contribution to journalArticle

Shah, SA, Doraiswamy, PM, Husain, MM, Figiel, GS, Boyko, O, McDonald, WM, Ellinwood, EH & Ranga Rama Krishnan, K 1991, 'Assessment of posterior fossa structures with midsagittal MRI: The effects of age', Neurobiology of Aging, vol. 12, no. 4, pp. 371-374. https://doi.org/10.1016/0197-4580(91)90025-F
Shah SA, Doraiswamy PM, Husain MM, Figiel GS, Boyko O, McDonald WM et al. Assessment of posterior fossa structures with midsagittal MRI: The effects of age. Neurobiology of Aging. 1991;12(4):371-374. https://doi.org/10.1016/0197-4580(91)90025-F
Shah, Sunjay A. ; Doraiswamy, P. Murali ; Husain, Mustafa M. ; Figiel, Gary S. ; Boyko, Orest ; McDonald, William M. ; Ellinwood, Everett H. ; Ranga Rama Krishnan, K. / Assessment of posterior fossa structures with midsagittal MRI : The effects of age. In: Neurobiology of Aging. 1991 ; Vol. 12, No. 4. pp. 371-374.
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