Assessment of Renal Injury With a Clinical Dual Head Lithotriptor Delivering 240 Shock Waves per Minute

Rajash Handa, James A. McAteer, Andrew Evan, Bret A. Connors, Yuri A. Pishchalnikov, Sujuan Gao

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: Lithotriptors with 2 treatment heads deliver shock waves along separate paths. Firing 1 head and then the other in alternating mode has been suggested as a strategy to treat stones twice as rapidly as with conventional shock wave lithotripsy. Because the shock wave rate is known to have a role in shock wave lithotripsy induced injury, and given that treatment using 2 separate shock wave sources exposes more renal tissue to shock wave energy than treatment with a conventional lithotriptor, we assessed renal trauma in pigs following treatment at rapid rate (240 shock waves per minute and 120 shock waves per minute per head) using a Duet lithotriptor (Direx Medical Systems, Petach Tikva, Israel) fired in alternating mode. Materials and Methods: Eight adult female pigs (Hardin Farms, Danville, Indiana) each were treated with sham shock wave lithotripsy or 2,400 shock waves delivered in alternating mode (1,200 shock waves per head, 120 shock waves per minute per head and 240 shock waves per minute overall at a power level of 10) to the lower renal pole. Renal functional parameters, including glomerular filtration rate and effective renal plasma flow, were determined before and 1 hour after shock wave lithotripsy. The kidneys were perfusion fixed in situ and the hemorrhagic lesion was quantified as a percent of functional renal volume. Results: Shock wave treatment resulted in no significant change in renal function and the response was similar to the functional response seen in sham shock wave treated animals. In 6 pigs treated with alternating mode the renal lesion was small at a mean ± SEM of 0.22% ± 0.09% of functional renal volume. Conclusions: Kidney tissue and function were minimally affected by a clinical dose of shock waves delivered in alternating mode (120 shock waves per minute per head and 240 shock waves per minute overall) with a Duet lithotriptor. These observations decrease concern that dual head lithotripsy at a rapid rate is inherently dangerous.

Original languageEnglish
Pages (from-to)884-889
Number of pages6
JournalJournal of Urology
Volume181
Issue number2
DOIs
StatePublished - Feb 2009

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Head
Kidney
Lithotripsy
Wounds and Injuries
Swine
Effective Renal Plasma Flow
Therapeutics
Israel
Glomerular Filtration Rate
Perfusion

Keywords

  • high-energy shock waves
  • instrumentation
  • kidney
  • lithotripsy
  • swine

ASJC Scopus subject areas

  • Urology

Cite this

Assessment of Renal Injury With a Clinical Dual Head Lithotriptor Delivering 240 Shock Waves per Minute. / Handa, Rajash; McAteer, James A.; Evan, Andrew; Connors, Bret A.; Pishchalnikov, Yuri A.; Gao, Sujuan.

In: Journal of Urology, Vol. 181, No. 2, 02.2009, p. 884-889.

Research output: Contribution to journalArticle

Handa, Rajash ; McAteer, James A. ; Evan, Andrew ; Connors, Bret A. ; Pishchalnikov, Yuri A. ; Gao, Sujuan. / Assessment of Renal Injury With a Clinical Dual Head Lithotriptor Delivering 240 Shock Waves per Minute. In: Journal of Urology. 2009 ; Vol. 181, No. 2. pp. 884-889.
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abstract = "Purpose: Lithotriptors with 2 treatment heads deliver shock waves along separate paths. Firing 1 head and then the other in alternating mode has been suggested as a strategy to treat stones twice as rapidly as with conventional shock wave lithotripsy. Because the shock wave rate is known to have a role in shock wave lithotripsy induced injury, and given that treatment using 2 separate shock wave sources exposes more renal tissue to shock wave energy than treatment with a conventional lithotriptor, we assessed renal trauma in pigs following treatment at rapid rate (240 shock waves per minute and 120 shock waves per minute per head) using a Duet lithotriptor (Direx Medical Systems, Petach Tikva, Israel) fired in alternating mode. Materials and Methods: Eight adult female pigs (Hardin Farms, Danville, Indiana) each were treated with sham shock wave lithotripsy or 2,400 shock waves delivered in alternating mode (1,200 shock waves per head, 120 shock waves per minute per head and 240 shock waves per minute overall at a power level of 10) to the lower renal pole. Renal functional parameters, including glomerular filtration rate and effective renal plasma flow, were determined before and 1 hour after shock wave lithotripsy. The kidneys were perfusion fixed in situ and the hemorrhagic lesion was quantified as a percent of functional renal volume. Results: Shock wave treatment resulted in no significant change in renal function and the response was similar to the functional response seen in sham shock wave treated animals. In 6 pigs treated with alternating mode the renal lesion was small at a mean ± SEM of 0.22{\%} ± 0.09{\%} of functional renal volume. Conclusions: Kidney tissue and function were minimally affected by a clinical dose of shock waves delivered in alternating mode (120 shock waves per minute per head and 240 shock waves per minute overall) with a Duet lithotriptor. These observations decrease concern that dual head lithotripsy at a rapid rate is inherently dangerous.",
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