Association between colorectal cancer susceptibility loci and survival time after diagnosis with colorectal cancer

Amanda I. Phipps, Polly A. Newcomb, Xabier Garcia-Albeniz, Carolyn M. Hutter, Emily White, Charles S. Fuchs, Aditi Hazra, Shuji Ogino, Hongmei Nan, Jing Ma, Peter T. Campbell, Jane C. Figueiredo, Ulrike Peters, Andrew T. Chan

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Genome-wide association studies have identified 16 germline single-nucleotide polymorphisms (SNPs) that are associated with colorectal cancer (CRC) incidence. We examined the relationship between these SNPs and survival of 2611 individuals with CRC, enrolled in 5 cohort studies. We used Cox regression analysis to associate SNPs with overall and CRC-specific survival times. The minor allele in rs4939827 (SMAD7) was associated with reduced overall survival (hazard ratio, 1.16; 95% confidence interval, 1.06-1.27; P =.002) and disease-specific survival (hazard ratio, 1.17; 95% confidence interval, 1.05-1.30; P =.005). Other SNPs were not associated significantly with survival. Common germline variations might be prognostic factors for patients with CRC. A variant in SMAD7 could affect progression of CRC.

Original languageEnglish (US)
Pages (from-to)51-54.e4
JournalGastroenterology
Volume143
Issue number1
DOIs
StatePublished - Jul 2012
Externally publishedYes

Keywords

  • Colon Cancer
  • GWAS
  • Genetic
  • Prognosis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Phipps, A. I., Newcomb, P. A., Garcia-Albeniz, X., Hutter, C. M., White, E., Fuchs, C. S., Hazra, A., Ogino, S., Nan, H., Ma, J., Campbell, P. T., Figueiredo, J. C., Peters, U., & Chan, A. T. (2012). Association between colorectal cancer susceptibility loci and survival time after diagnosis with colorectal cancer. Gastroenterology, 143(1), 51-54.e4. https://doi.org/10.1053/j.gastro.2012.04.052