Association between colorectal cancer susceptibility loci and survival time after diagnosis with colorectal cancer

Amanda I. Phipps, Polly A. Newcomb, Xabier Garcia-Albeniz, Carolyn M. Hutter, Emily White, Charles S. Fuchs, Aditi Hazra, Shuji Ogino, Hongmei Nan, Jing Ma, Peter T. Campbell, Jane C. Figueiredo, Ulrike Peters, Andrew T. Chan

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Genome-wide association studies have identified 16 germline single-nucleotide polymorphisms (SNPs) that are associated with colorectal cancer (CRC) incidence. We examined the relationship between these SNPs and survival of 2611 individuals with CRC, enrolled in 5 cohort studies. We used Cox regression analysis to associate SNPs with overall and CRC-specific survival times. The minor allele in rs4939827 (SMAD7) was associated with reduced overall survival (hazard ratio, 1.16; 95% confidence interval, 1.06-1.27; P =.002) and disease-specific survival (hazard ratio, 1.17; 95% confidence interval, 1.05-1.30; P =.005). Other SNPs were not associated significantly with survival. Common germline variations might be prognostic factors for patients with CRC. A variant in SMAD7 could affect progression of CRC.

Original languageEnglish (US)
JournalGastroenterology
Volume143
Issue number1
DOIs
StatePublished - Jul 1 2012
Externally publishedYes

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Colorectal Neoplasms
Single Nucleotide Polymorphism
Survival
Confidence Intervals
Genome-Wide Association Study
Cohort Studies
Alleles
Regression Analysis
Incidence

Keywords

  • Colon Cancer
  • Genetic
  • GWAS
  • Prognosis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Phipps, A. I., Newcomb, P. A., Garcia-Albeniz, X., Hutter, C. M., White, E., Fuchs, C. S., ... Chan, A. T. (2012). Association between colorectal cancer susceptibility loci and survival time after diagnosis with colorectal cancer. Gastroenterology, 143(1). https://doi.org/10.1053/j.gastro.2012.04.052

Association between colorectal cancer susceptibility loci and survival time after diagnosis with colorectal cancer. / Phipps, Amanda I.; Newcomb, Polly A.; Garcia-Albeniz, Xabier; Hutter, Carolyn M.; White, Emily; Fuchs, Charles S.; Hazra, Aditi; Ogino, Shuji; Nan, Hongmei; Ma, Jing; Campbell, Peter T.; Figueiredo, Jane C.; Peters, Ulrike; Chan, Andrew T.

In: Gastroenterology, Vol. 143, No. 1, 01.07.2012.

Research output: Contribution to journalArticle

Phipps, AI, Newcomb, PA, Garcia-Albeniz, X, Hutter, CM, White, E, Fuchs, CS, Hazra, A, Ogino, S, Nan, H, Ma, J, Campbell, PT, Figueiredo, JC, Peters, U & Chan, AT 2012, 'Association between colorectal cancer susceptibility loci and survival time after diagnosis with colorectal cancer', Gastroenterology, vol. 143, no. 1. https://doi.org/10.1053/j.gastro.2012.04.052
Phipps, Amanda I. ; Newcomb, Polly A. ; Garcia-Albeniz, Xabier ; Hutter, Carolyn M. ; White, Emily ; Fuchs, Charles S. ; Hazra, Aditi ; Ogino, Shuji ; Nan, Hongmei ; Ma, Jing ; Campbell, Peter T. ; Figueiredo, Jane C. ; Peters, Ulrike ; Chan, Andrew T. / Association between colorectal cancer susceptibility loci and survival time after diagnosis with colorectal cancer. In: Gastroenterology. 2012 ; Vol. 143, No. 1.
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