Association Between Endoscopic and Histologic Findings in a Multicenter Retrospective Cohort of Patients with Non-esophageal Eosinophilic Gastrointestinal Disorders

the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)

Research output: Contribution to journalArticle

Abstract

Background: Little is known about the endoscopic and histologic findings of non-esophageal eosinophilic gastrointestinal diseases (EGID). Aim: To characterize the presenting endoscopic and histologic findings in patients with eosinophilic gastritis (EG), eosinophilic gastroenteritis (EGE), and eosinophilic colitis (EC) at diagnosis and 6 months after initiating the treatment. Methods: We conducted a retrospective cohort study at 6 US centers associated with the Consortium of Eosinophilic Gastrointestinal Researchers. Data abstracted included demographics, endoscopic findings, tissue eosinophil counts, and associated histologic findings at diagnosis and, when available, after initial treatment. Results: Of 373 subjects (317 children and 56 adults), 142 had EG, 123 EGE, and 108 EC. Normal endoscopic appearance was the most common finding across all EGIDs (62% of subjects). Baseline tissue eosinophil counts were quantified in 105 (74%) EG, 36 (29%) EGE, and 80 (74%) EC subjects. The mean peak gastric eosinophil count across all sites was 87 eos/hpf for EG and 78 eos/hpf for EGE. The mean peak colonic eosinophil count for EC subjects was 76 eos/hpf (range 10–500). Of the 29% of subjects with post-treatment follow-up, most had an improvement in clinical, endoscopic, and histologic findings regardless of treatment utilized. Reductions in tissue eosinophilia correlated with improvements in clinical symptoms as well as endoscopic and histologic findings. Conclusions: In this large cohort, normal appearance was the most common endoscopic finding, emphasizing the importance of biopsy, regardless of endoscopic appearance. Decreased tissue eosinophilia was associated with improvement in symptoms, endoscopic, and histologic findings, showing that disease activity is reversible.

Original languageEnglish (US)
JournalDigestive Diseases and Sciences
DOIs
StateAccepted/In press - Jan 1 2019

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Colitis
Eosinophils
Eosinophilia
Eosinophilic enteropathy
Gastrointestinal Diseases
Therapeutics
Stomach
Cohort Studies
Retrospective Studies
Research Personnel
Demography
Biopsy

Keywords

  • Eosinophilic colitis
  • Eosinophilic esophagitis
  • Eosinophilic gastritis
  • Eosinophilic gastroenteritis

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Association Between Endoscopic and Histologic Findings in a Multicenter Retrospective Cohort of Patients with Non-esophageal Eosinophilic Gastrointestinal Disorders. / the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR).

In: Digestive Diseases and Sciences, 01.01.2019.

Research output: Contribution to journalArticle

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title = "Association Between Endoscopic and Histologic Findings in a Multicenter Retrospective Cohort of Patients with Non-esophageal Eosinophilic Gastrointestinal Disorders",
abstract = "Background: Little is known about the endoscopic and histologic findings of non-esophageal eosinophilic gastrointestinal diseases (EGID). Aim: To characterize the presenting endoscopic and histologic findings in patients with eosinophilic gastritis (EG), eosinophilic gastroenteritis (EGE), and eosinophilic colitis (EC) at diagnosis and 6 months after initiating the treatment. Methods: We conducted a retrospective cohort study at 6 US centers associated with the Consortium of Eosinophilic Gastrointestinal Researchers. Data abstracted included demographics, endoscopic findings, tissue eosinophil counts, and associated histologic findings at diagnosis and, when available, after initial treatment. Results: Of 373 subjects (317 children and 56 adults), 142 had EG, 123 EGE, and 108 EC. Normal endoscopic appearance was the most common finding across all EGIDs (62{\%} of subjects). Baseline tissue eosinophil counts were quantified in 105 (74{\%}) EG, 36 (29{\%}) EGE, and 80 (74{\%}) EC subjects. The mean peak gastric eosinophil count across all sites was 87 eos/hpf for EG and 78 eos/hpf for EGE. The mean peak colonic eosinophil count for EC subjects was 76 eos/hpf (range 10–500). Of the 29{\%} of subjects with post-treatment follow-up, most had an improvement in clinical, endoscopic, and histologic findings regardless of treatment utilized. Reductions in tissue eosinophilia correlated with improvements in clinical symptoms as well as endoscopic and histologic findings. Conclusions: In this large cohort, normal appearance was the most common endoscopic finding, emphasizing the importance of biopsy, regardless of endoscopic appearance. Decreased tissue eosinophilia was associated with improvement in symptoms, endoscopic, and histologic findings, showing that disease activity is reversible.",
keywords = "Eosinophilic colitis, Eosinophilic esophagitis, Eosinophilic gastritis, Eosinophilic gastroenteritis",
author = "{the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)} and Pesek, {Robert D.} and Reed, {Craig C.} and Collins, {Margaret H.} and Muir, {Amanda B.} and Fulkerson, {Patricia C.} and Calies Menard-Katcher and Falk, {Gary W.} and Jonathan Kuhl and Magier, {Adam Z.} and Ahmed, {Faria N.} and Maureen Demarshall and Ankur Gupta and Jonathan Gross and Tokunbo Ashorobi and Carpenter, {Christina L.} and Krischer, {Jeffrey P.} and Nirmala Gonsalves and Ikuo Hirano and Spergel, {Jonathan M.} and Gupta, {Sandeep K.} and Furuta, {Glenn T.} and Rothenberg, {Marc E.} and Dellon, {Evan S.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s10620-019-05961-4",
language = "English (US)",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
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T1 - Association Between Endoscopic and Histologic Findings in a Multicenter Retrospective Cohort of Patients with Non-esophageal Eosinophilic Gastrointestinal Disorders

AU - the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)

AU - Pesek, Robert D.

AU - Reed, Craig C.

AU - Collins, Margaret H.

AU - Muir, Amanda B.

AU - Fulkerson, Patricia C.

AU - Menard-Katcher, Calies

AU - Falk, Gary W.

AU - Kuhl, Jonathan

AU - Magier, Adam Z.

AU - Ahmed, Faria N.

AU - Demarshall, Maureen

AU - Gupta, Ankur

AU - Gross, Jonathan

AU - Ashorobi, Tokunbo

AU - Carpenter, Christina L.

AU - Krischer, Jeffrey P.

AU - Gonsalves, Nirmala

AU - Hirano, Ikuo

AU - Spergel, Jonathan M.

AU - Gupta, Sandeep K.

AU - Furuta, Glenn T.

AU - Rothenberg, Marc E.

AU - Dellon, Evan S.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Little is known about the endoscopic and histologic findings of non-esophageal eosinophilic gastrointestinal diseases (EGID). Aim: To characterize the presenting endoscopic and histologic findings in patients with eosinophilic gastritis (EG), eosinophilic gastroenteritis (EGE), and eosinophilic colitis (EC) at diagnosis and 6 months after initiating the treatment. Methods: We conducted a retrospective cohort study at 6 US centers associated with the Consortium of Eosinophilic Gastrointestinal Researchers. Data abstracted included demographics, endoscopic findings, tissue eosinophil counts, and associated histologic findings at diagnosis and, when available, after initial treatment. Results: Of 373 subjects (317 children and 56 adults), 142 had EG, 123 EGE, and 108 EC. Normal endoscopic appearance was the most common finding across all EGIDs (62% of subjects). Baseline tissue eosinophil counts were quantified in 105 (74%) EG, 36 (29%) EGE, and 80 (74%) EC subjects. The mean peak gastric eosinophil count across all sites was 87 eos/hpf for EG and 78 eos/hpf for EGE. The mean peak colonic eosinophil count for EC subjects was 76 eos/hpf (range 10–500). Of the 29% of subjects with post-treatment follow-up, most had an improvement in clinical, endoscopic, and histologic findings regardless of treatment utilized. Reductions in tissue eosinophilia correlated with improvements in clinical symptoms as well as endoscopic and histologic findings. Conclusions: In this large cohort, normal appearance was the most common endoscopic finding, emphasizing the importance of biopsy, regardless of endoscopic appearance. Decreased tissue eosinophilia was associated with improvement in symptoms, endoscopic, and histologic findings, showing that disease activity is reversible.

AB - Background: Little is known about the endoscopic and histologic findings of non-esophageal eosinophilic gastrointestinal diseases (EGID). Aim: To characterize the presenting endoscopic and histologic findings in patients with eosinophilic gastritis (EG), eosinophilic gastroenteritis (EGE), and eosinophilic colitis (EC) at diagnosis and 6 months after initiating the treatment. Methods: We conducted a retrospective cohort study at 6 US centers associated with the Consortium of Eosinophilic Gastrointestinal Researchers. Data abstracted included demographics, endoscopic findings, tissue eosinophil counts, and associated histologic findings at diagnosis and, when available, after initial treatment. Results: Of 373 subjects (317 children and 56 adults), 142 had EG, 123 EGE, and 108 EC. Normal endoscopic appearance was the most common finding across all EGIDs (62% of subjects). Baseline tissue eosinophil counts were quantified in 105 (74%) EG, 36 (29%) EGE, and 80 (74%) EC subjects. The mean peak gastric eosinophil count across all sites was 87 eos/hpf for EG and 78 eos/hpf for EGE. The mean peak colonic eosinophil count for EC subjects was 76 eos/hpf (range 10–500). Of the 29% of subjects with post-treatment follow-up, most had an improvement in clinical, endoscopic, and histologic findings regardless of treatment utilized. Reductions in tissue eosinophilia correlated with improvements in clinical symptoms as well as endoscopic and histologic findings. Conclusions: In this large cohort, normal appearance was the most common endoscopic finding, emphasizing the importance of biopsy, regardless of endoscopic appearance. Decreased tissue eosinophilia was associated with improvement in symptoms, endoscopic, and histologic findings, showing that disease activity is reversible.

KW - Eosinophilic colitis

KW - Eosinophilic esophagitis

KW - Eosinophilic gastritis

KW - Eosinophilic gastroenteritis

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U2 - 10.1007/s10620-019-05961-4

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