Association between Helicobacter pylori infection and liver cancer mortality in 67 rural Chinese counties

Ling Wang, Terrell Zollinger, Jianjun Zhang 

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Although a growing body of evidence from experimental and clinical studies suggests that Helicobacter pylori may play a role in liver cancer etiology, few epidemiologic studies have investigated this hypothesis. Methods: Liver cancer mortality rates in 1986-1988 for the 67 Chinese counties were obtained from a nationwide survey among subjects aged 35-69 years. Blood samples were collected from selected individuals of the similar age range in the same 67 counties in 1989. H. pylori infection was evaluated by measuring its antibodies (IgG) in plasma samples using an enzyme-linked immunosorbent assay (ELISA). Pearson correlation and multiple regression analyses were performed to test our hypothesis. Results: Prevalence rates of H. pylori infection were positively correlated with liver cancer mortality in both men (r = 0.43, p = 0.0002) and women (r = 0.41, p = 0.0005). This significant association persisted after adjustment for body mass index, income, cigarette smoking, alcohol consumption, HBsAg positivity, diabetes mortality, and salt-preserved vegetable intake. Stratified analysis revealed suggestive interactions of H. pylori prevalence with HBsAg positivity and urinary aflatoxin M1 in men in relation to liver cancer mortality. Conclusion: The present study offers novel epidemiologic evidence suggesting that infection with H. pylori is associated with an increased risk of death from liver cancer among rural Chinese residents.

Original languageEnglish
Pages (from-to)1331-1337
Number of pages7
JournalCancer Causes and Control
Volume24
Issue number7
DOIs
StatePublished - Jul 2013

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Helicobacter Infections
Liver Neoplasms
Helicobacter pylori
Mortality
Hepatitis B Surface Antigens
Aflatoxin M1
Alcohol Drinking
Vegetables
Epidemiologic Studies
Body Mass Index
Salts
Immunoglobulin G
Smoking
Enzyme-Linked Immunosorbent Assay
Regression Analysis
Antibodies
Infection

Keywords

  • And rural Chinese
  • Cancer epidemiology
  • Cancer etiology
  • Helicobacter pylori infection
  • Liver cancer mortality

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Association between Helicobacter pylori infection and liver cancer mortality in 67 rural Chinese counties. / Wang, Ling; Zollinger, Terrell; Zhang , Jianjun.

In: Cancer Causes and Control, Vol. 24, No. 7, 07.2013, p. 1331-1337.

Research output: Contribution to journalArticle

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