Association between metabolic syndrome and its individual components with viral hepatitis B

Raxitkumar Jinjuvadia, Suthat Liangpunsakul

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

BACKGROUND:: The association between hepatitis B and metabolic syndrome (MetS) has not been well described. Overall epidemiologic evidences for this association have suggested conflicting results. The aim this study was to determine the association between hepatitis B infection and MetS using large U.S. population database, the Third National Health and Nutrition Examination Survey. METHODS:: Individuals aged ≥18 years were included in this study. MetS was defined according to the Third Report of the National Cholesterol Education Program Adult Treatment Panel guideline. The chronic hepatitis B was defined as the presence of hepatitis B surface antigen. The presence of hepatitis B core antibody with/without surface antibody, in the absence of surface antigen, was considered as past exposure to hepatitis B. To represent national estimates, weighted frequencies for chronic hepatitis B and past exposure to hepatitis B are reported. Multivariate logistic regression analysis accounting for age, gender, race, smoking and alcohol status was conducted to identify the independent predictor(s) of MetS. RESULTS:: This study cohort consisted of total population of 593,594 with chronic hepatitis B and 7,280,620 with past exposure to hepatitis B. Prevalence of MetS among included study cohort was 25.7%. Inverse association was observed between MetS and chronic hepatitis B (adjusted odds ratio, 0.32; 95% confidence interval, 0.12-0.84). Among individual components of MetS, waist circumference was inversely associated with chronic hepatitis B (adjusted odds ratio, 0.31; 95% confidence interval, 0.14-0.71). No significant association was noted between past exposure to hepatitis B and MetS or its individual components. CONCLUSIONS:: In this study, the authors noted significant inverse association between MetS and chronic hepatitis B.

Original languageEnglish
Pages (from-to)23-27
Number of pages5
JournalAmerican Journal of the Medical Sciences
Volume347
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Viral Structures
Hepatitis B
Chronic Hepatitis B
Cohort Studies
Odds Ratio
Confidence Intervals
Hepatitis B Antibodies
Nutrition Surveys
Waist Circumference
Surface Antigens
Hepatitis B Surface Antigens
Population
Logistic Models
Smoking
Cholesterol
Regression Analysis
Alcohols
Databases
Guidelines
Education

Keywords

  • Hepatitis B
  • Metabolic syndrome
  • NHANES III

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Association between metabolic syndrome and its individual components with viral hepatitis B. / Jinjuvadia, Raxitkumar; Liangpunsakul, Suthat.

In: American Journal of the Medical Sciences, Vol. 347, No. 1, 01.2014, p. 23-27.

Research output: Contribution to journalArticle

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abstract = "BACKGROUND:: The association between hepatitis B and metabolic syndrome (MetS) has not been well described. Overall epidemiologic evidences for this association have suggested conflicting results. The aim this study was to determine the association between hepatitis B infection and MetS using large U.S. population database, the Third National Health and Nutrition Examination Survey. METHODS:: Individuals aged ≥18 years were included in this study. MetS was defined according to the Third Report of the National Cholesterol Education Program Adult Treatment Panel guideline. The chronic hepatitis B was defined as the presence of hepatitis B surface antigen. The presence of hepatitis B core antibody with/without surface antibody, in the absence of surface antigen, was considered as past exposure to hepatitis B. To represent national estimates, weighted frequencies for chronic hepatitis B and past exposure to hepatitis B are reported. Multivariate logistic regression analysis accounting for age, gender, race, smoking and alcohol status was conducted to identify the independent predictor(s) of MetS. RESULTS:: This study cohort consisted of total population of 593,594 with chronic hepatitis B and 7,280,620 with past exposure to hepatitis B. Prevalence of MetS among included study cohort was 25.7{\%}. Inverse association was observed between MetS and chronic hepatitis B (adjusted odds ratio, 0.32; 95{\%} confidence interval, 0.12-0.84). Among individual components of MetS, waist circumference was inversely associated with chronic hepatitis B (adjusted odds ratio, 0.31; 95{\%} confidence interval, 0.14-0.71). No significant association was noted between past exposure to hepatitis B and MetS or its individual components. CONCLUSIONS:: In this study, the authors noted significant inverse association between MetS and chronic hepatitis B.",
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