Association between periodontitis and chronic obstructive pulmonary disease in a Chinese population

Yan Si, Hong Fan, Yiqing Song, Xuan Zhou, Jing Zhang, Zuomin Wang

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: A relationship between periodontitis and chronic respiratory disease has been suggested by recent studies. The aim of this study is to explore the association between periodontitis and chronic obstructive pulmonary disease (COPD) in a Chinese population. Methods: We conducted a case-control study of 581 COPD cases and 438 non-COPD controls. Lung function examination, a 6-minute walk test, and the British Medical Research Council questionnaire were performed. Periodontal clinical examination index included probing depth (PD), attachment loss (AL), bleeding index (BI), plaque index (PI), and alveolar bone loss. A validated index for predicting COPD prognosis, the body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE) index, was also calculated. Results: Participants with more severe COPD were more likely to have severe periodontal disease. PD, AL, PI, alveolar bone loss, and the number of teeth were significantly associated with all stages of COPD (all P <0.001). When compared to controls (BODE = 0), participants with higher BODE scores had significantly higher AL (P <0.001), BI (P = 0.027), PI (P <0.001), alveolar bone loss (P <0.001), and the number of teeth (P <0.001). PI appeared to be the main periodontal health-related factor for COPD, with an odds ratio (OR) = 9.01 (95% CI = 3.98 to 20.4) in the entire study population OR = 8.28 (95% CI = 2.36 to 29.0), OR = 5.89 (95% CI = 2.64 to 13.1), and OR = 2.46 (95% CI = 1.47 to 4.10) for current, smokers, and non-smokers, respectively. Conclusion: Our study found a strong association between periodontitis and COPD, and PI seemed to be a major periodontal factor for predicting COPD among Chinese adults.

Original languageEnglish (US)
Pages (from-to)1288-1296
Number of pages9
JournalJournal of Periodontology
Volume83
Issue number10
DOIs
StatePublished - Oct 1 2012
Externally publishedYes

Fingerprint

Periodontitis
Chronic Obstructive Pulmonary Disease
Alveolar Bone Loss
Population
Odds Ratio
Tooth
Hemorrhage
Obstructive Lung Diseases
Periodontal Diseases
Dyspnea
Case-Control Studies
Biomedical Research
Body Mass Index
Chronic Disease
Exercise
Lung
Health

Keywords

  • Periodontitis
  • Pulmonary disease,chronic obstructive
  • Respiratory function tests

ASJC Scopus subject areas

  • Periodontics

Cite this

Association between periodontitis and chronic obstructive pulmonary disease in a Chinese population. / Si, Yan; Fan, Hong; Song, Yiqing; Zhou, Xuan; Zhang, Jing; Wang, Zuomin.

In: Journal of Periodontology, Vol. 83, No. 10, 01.10.2012, p. 1288-1296.

Research output: Contribution to journalArticle

Si, Yan ; Fan, Hong ; Song, Yiqing ; Zhou, Xuan ; Zhang, Jing ; Wang, Zuomin. / Association between periodontitis and chronic obstructive pulmonary disease in a Chinese population. In: Journal of Periodontology. 2012 ; Vol. 83, No. 10. pp. 1288-1296.
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abstract = "Background: A relationship between periodontitis and chronic respiratory disease has been suggested by recent studies. The aim of this study is to explore the association between periodontitis and chronic obstructive pulmonary disease (COPD) in a Chinese population. Methods: We conducted a case-control study of 581 COPD cases and 438 non-COPD controls. Lung function examination, a 6-minute walk test, and the British Medical Research Council questionnaire were performed. Periodontal clinical examination index included probing depth (PD), attachment loss (AL), bleeding index (BI), plaque index (PI), and alveolar bone loss. A validated index for predicting COPD prognosis, the body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE) index, was also calculated. Results: Participants with more severe COPD were more likely to have severe periodontal disease. PD, AL, PI, alveolar bone loss, and the number of teeth were significantly associated with all stages of COPD (all P <0.001). When compared to controls (BODE = 0), participants with higher BODE scores had significantly higher AL (P <0.001), BI (P = 0.027), PI (P <0.001), alveolar bone loss (P <0.001), and the number of teeth (P <0.001). PI appeared to be the main periodontal health-related factor for COPD, with an odds ratio (OR) = 9.01 (95{\%} CI = 3.98 to 20.4) in the entire study population OR = 8.28 (95{\%} CI = 2.36 to 29.0), OR = 5.89 (95{\%} CI = 2.64 to 13.1), and OR = 2.46 (95{\%} CI = 1.47 to 4.10) for current, smokers, and non-smokers, respectively. Conclusion: Our study found a strong association between periodontitis and COPD, and PI seemed to be a major periodontal factor for predicting COPD among Chinese adults.",
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AU - Zhou, Xuan

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AU - Wang, Zuomin

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