Association between reproductive cancer and fetal outcomes: A systematic review

Mulubrhan F. Mogos, Shams Rahman, Hamisu M. Salihu, Abraham A. Salinas-Miranda, Dawood H. Sultan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: This study aimed to review studies that addressed the impact of previous reproductive cancer diagnosis on selected fetal birth outcomes. Materials and Methods: We searched PubMed and Web of Knowledge to identify peerreviewed articles published from January 1992 to December 2012, investigating the association between reproductive cancer and birth outcomes. After applying exclusion criteria, 49 articles were identified for full review, and 36 articles were finally selected for this systematic review. The quality of the studies was assessed by independent reviewers. Results: We found 13 cervical cancer studies, 16 ovarian cancer studies, and 7 corpus uteri cancers that reported subsequent pregnancies (n = 688 pregnancies in 477 women). Of these, 489 pregnancies reached third trimester. Among viable pregnancies, only 416 pregnancies had information on maturity status based on gestational age and/or birth weight. For those with cervical cancer, the preterm birth (PTB) rate was 48.5%. For those with ovarian cancer, there were no cases of PTB. For those with corpus uteri cancers, the PTB was 7.7%. All studies had small sample sizes, and there was considerable heterogeneity of results. Abortions, ectopic pregnancies, and terminations were also reported. Conclusions: Reproductive cancers may be associated to subsequent adverse fetal birth outcomes; however, the quality of evidence is still insufficient to infer a relationship between reproductive cancers treated conservatively and adverse fetal birth outcomes in subsequent pregnancies.

Original languageEnglish (US)
Pages (from-to)1171-1177
Number of pages7
JournalInternational Journal of Gynecological Cancer
Volume23
Issue number7
DOIs
StatePublished - Sep 2013
Externally publishedYes

Fingerprint

Premature Birth
Pregnancy
Parturition
Uterine Neoplasms
Neoplasms
Uterine Cervical Neoplasms
Ovarian Neoplasms
Ectopic Pregnancy
Birth Rate
Third Pregnancy Trimester
PubMed
Birth Weight
Sample Size
Gestational Age

Keywords

  • Fetal outcomes
  • Low birth weight
  • Pregnancy
  • Preterm
  • Reproductive cancer
  • Small size for gestational age

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Association between reproductive cancer and fetal outcomes : A systematic review. / Mogos, Mulubrhan F.; Rahman, Shams; Salihu, Hamisu M.; Salinas-Miranda, Abraham A.; Sultan, Dawood H.

In: International Journal of Gynecological Cancer, Vol. 23, No. 7, 09.2013, p. 1171-1177.

Research output: Contribution to journalArticle

Mogos, Mulubrhan F. ; Rahman, Shams ; Salihu, Hamisu M. ; Salinas-Miranda, Abraham A. ; Sultan, Dawood H. / Association between reproductive cancer and fetal outcomes : A systematic review. In: International Journal of Gynecological Cancer. 2013 ; Vol. 23, No. 7. pp. 1171-1177.
@article{d3ad54874bd84e468ed9d2734882f6e6,
title = "Association between reproductive cancer and fetal outcomes: A systematic review",
abstract = "Objective: This study aimed to review studies that addressed the impact of previous reproductive cancer diagnosis on selected fetal birth outcomes. Materials and Methods: We searched PubMed and Web of Knowledge to identify peerreviewed articles published from January 1992 to December 2012, investigating the association between reproductive cancer and birth outcomes. After applying exclusion criteria, 49 articles were identified for full review, and 36 articles were finally selected for this systematic review. The quality of the studies was assessed by independent reviewers. Results: We found 13 cervical cancer studies, 16 ovarian cancer studies, and 7 corpus uteri cancers that reported subsequent pregnancies (n = 688 pregnancies in 477 women). Of these, 489 pregnancies reached third trimester. Among viable pregnancies, only 416 pregnancies had information on maturity status based on gestational age and/or birth weight. For those with cervical cancer, the preterm birth (PTB) rate was 48.5{\%}. For those with ovarian cancer, there were no cases of PTB. For those with corpus uteri cancers, the PTB was 7.7{\%}. All studies had small sample sizes, and there was considerable heterogeneity of results. Abortions, ectopic pregnancies, and terminations were also reported. Conclusions: Reproductive cancers may be associated to subsequent adverse fetal birth outcomes; however, the quality of evidence is still insufficient to infer a relationship between reproductive cancers treated conservatively and adverse fetal birth outcomes in subsequent pregnancies.",
keywords = "Fetal outcomes, Low birth weight, Pregnancy, Preterm, Reproductive cancer, Small size for gestational age",
author = "Mogos, {Mulubrhan F.} and Shams Rahman and Salihu, {Hamisu M.} and Salinas-Miranda, {Abraham A.} and Sultan, {Dawood H.}",
year = "2013",
month = "9",
doi = "10.1097/IGC.0b013e31829e9fe2",
language = "English (US)",
volume = "23",
pages = "1171--1177",
journal = "International Journal of Gynecological Cancer",
issn = "1048-891X",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Association between reproductive cancer and fetal outcomes

T2 - A systematic review

AU - Mogos, Mulubrhan F.

AU - Rahman, Shams

AU - Salihu, Hamisu M.

AU - Salinas-Miranda, Abraham A.

AU - Sultan, Dawood H.

PY - 2013/9

Y1 - 2013/9

N2 - Objective: This study aimed to review studies that addressed the impact of previous reproductive cancer diagnosis on selected fetal birth outcomes. Materials and Methods: We searched PubMed and Web of Knowledge to identify peerreviewed articles published from January 1992 to December 2012, investigating the association between reproductive cancer and birth outcomes. After applying exclusion criteria, 49 articles were identified for full review, and 36 articles were finally selected for this systematic review. The quality of the studies was assessed by independent reviewers. Results: We found 13 cervical cancer studies, 16 ovarian cancer studies, and 7 corpus uteri cancers that reported subsequent pregnancies (n = 688 pregnancies in 477 women). Of these, 489 pregnancies reached third trimester. Among viable pregnancies, only 416 pregnancies had information on maturity status based on gestational age and/or birth weight. For those with cervical cancer, the preterm birth (PTB) rate was 48.5%. For those with ovarian cancer, there were no cases of PTB. For those with corpus uteri cancers, the PTB was 7.7%. All studies had small sample sizes, and there was considerable heterogeneity of results. Abortions, ectopic pregnancies, and terminations were also reported. Conclusions: Reproductive cancers may be associated to subsequent adverse fetal birth outcomes; however, the quality of evidence is still insufficient to infer a relationship between reproductive cancers treated conservatively and adverse fetal birth outcomes in subsequent pregnancies.

AB - Objective: This study aimed to review studies that addressed the impact of previous reproductive cancer diagnosis on selected fetal birth outcomes. Materials and Methods: We searched PubMed and Web of Knowledge to identify peerreviewed articles published from January 1992 to December 2012, investigating the association between reproductive cancer and birth outcomes. After applying exclusion criteria, 49 articles were identified for full review, and 36 articles were finally selected for this systematic review. The quality of the studies was assessed by independent reviewers. Results: We found 13 cervical cancer studies, 16 ovarian cancer studies, and 7 corpus uteri cancers that reported subsequent pregnancies (n = 688 pregnancies in 477 women). Of these, 489 pregnancies reached third trimester. Among viable pregnancies, only 416 pregnancies had information on maturity status based on gestational age and/or birth weight. For those with cervical cancer, the preterm birth (PTB) rate was 48.5%. For those with ovarian cancer, there were no cases of PTB. For those with corpus uteri cancers, the PTB was 7.7%. All studies had small sample sizes, and there was considerable heterogeneity of results. Abortions, ectopic pregnancies, and terminations were also reported. Conclusions: Reproductive cancers may be associated to subsequent adverse fetal birth outcomes; however, the quality of evidence is still insufficient to infer a relationship between reproductive cancers treated conservatively and adverse fetal birth outcomes in subsequent pregnancies.

KW - Fetal outcomes

KW - Low birth weight

KW - Pregnancy

KW - Preterm

KW - Reproductive cancer

KW - Small size for gestational age

UR - http://www.scopus.com/inward/record.url?scp=84884513556&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884513556&partnerID=8YFLogxK

U2 - 10.1097/IGC.0b013e31829e9fe2

DO - 10.1097/IGC.0b013e31829e9fe2

M3 - Article

C2 - 23970154

AN - SCOPUS:84884513556

VL - 23

SP - 1171

EP - 1177

JO - International Journal of Gynecological Cancer

JF - International Journal of Gynecological Cancer

SN - 1048-891X

IS - 7

ER -