Association between XPF polymorphisms and cancer risk: A meta-analysis

Ting Yan Shi, Jing He, Li Xin Qiu, Mei Ling Zhu, Meng Yun Wang, Xiao Yan Zhou, Jiali Han, Hongpin Yu, Rong Yu Zang, Qingyi Wei

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Xeroderma pigmentosum complementation group F (XPF or ERCC4) plays a key role in DNA repair that protects against genetic instability and carcinogenesis. A series of epidemiological studies have examined associations between XPF polymorphisms and cancer risk, but the findings remain inconclusive. Methodology/Principal Findings: In this meta-analysis of 47,639 cancer cases and 51,915 controls, by searching three electronic databases (i.e., MEDLINE, EMBASE and CNKI), we summarized 43 case-control studies from 29 publications on four commonly studied polymorphisms of XPF (i.e., rs1800067, rs1799801, rs2020955 and rs744154), and we did not find statistical evidence of any significant association with overall cancer risk. However, in stratification analyses, we found a significant association of XPF-rs1799801 with a reduced cancer risk in Caucasian populations (4,845 cases and 5,556 controls; recessive model: OR = 0.87, 95% CI = 0.76-1.00, P = 0.049, P = 0.723 for heterogeneity test, I2 = 0). Further genotype-phenotype correlation analysis showed that the homozygous variant CC genotype carriers had higher XPF expression levels than that of the TT genotype carriers (Student's t test for a recessive model: P = 0.046). No publication bias was found by using the funnel plot and Egger's test. Conclusion: This meta-analysis suggests a lack of statistical evidence for the association between the four XPF SNPs and overall risk of cancers. However, XPF-rs1799801 may be associated with cancer risk in Caucasian populations, which needs to be further validated in single large, well-designed prospective studies.

Original languageEnglish (US)
Article numbere38606
JournalPLoS One
Volume7
Issue number7
DOIs
StatePublished - Jul 2 2012
Externally publishedYes

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Polymorphism
meta-analysis
Meta-Analysis
genetic polymorphism
neoplasms
Neoplasms
Genotype
Publication Bias
genotype
Genetic Association Studies
DNA repair
case-control studies
prospective studies
MEDLINE
Repair
DNA Repair
carcinogenesis
epidemiological studies
Population
electronics

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Shi, T. Y., He, J., Qiu, L. X., Zhu, M. L., Wang, M. Y., Zhou, X. Y., ... Wei, Q. (2012). Association between XPF polymorphisms and cancer risk: A meta-analysis. PLoS One, 7(7), [e38606]. https://doi.org/10.1371/journal.pone.0038606

Association between XPF polymorphisms and cancer risk : A meta-analysis. / Shi, Ting Yan; He, Jing; Qiu, Li Xin; Zhu, Mei Ling; Wang, Meng Yun; Zhou, Xiao Yan; Han, Jiali; Yu, Hongpin; Zang, Rong Yu; Wei, Qingyi.

In: PLoS One, Vol. 7, No. 7, e38606, 02.07.2012.

Research output: Contribution to journalArticle

Shi, TY, He, J, Qiu, LX, Zhu, ML, Wang, MY, Zhou, XY, Han, J, Yu, H, Zang, RY & Wei, Q 2012, 'Association between XPF polymorphisms and cancer risk: A meta-analysis', PLoS One, vol. 7, no. 7, e38606. https://doi.org/10.1371/journal.pone.0038606
Shi TY, He J, Qiu LX, Zhu ML, Wang MY, Zhou XY et al. Association between XPF polymorphisms and cancer risk: A meta-analysis. PLoS One. 2012 Jul 2;7(7). e38606. https://doi.org/10.1371/journal.pone.0038606
Shi, Ting Yan ; He, Jing ; Qiu, Li Xin ; Zhu, Mei Ling ; Wang, Meng Yun ; Zhou, Xiao Yan ; Han, Jiali ; Yu, Hongpin ; Zang, Rong Yu ; Wei, Qingyi. / Association between XPF polymorphisms and cancer risk : A meta-analysis. In: PLoS One. 2012 ; Vol. 7, No. 7.
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abstract = "Background: Xeroderma pigmentosum complementation group F (XPF or ERCC4) plays a key role in DNA repair that protects against genetic instability and carcinogenesis. A series of epidemiological studies have examined associations between XPF polymorphisms and cancer risk, but the findings remain inconclusive. Methodology/Principal Findings: In this meta-analysis of 47,639 cancer cases and 51,915 controls, by searching three electronic databases (i.e., MEDLINE, EMBASE and CNKI), we summarized 43 case-control studies from 29 publications on four commonly studied polymorphisms of XPF (i.e., rs1800067, rs1799801, rs2020955 and rs744154), and we did not find statistical evidence of any significant association with overall cancer risk. However, in stratification analyses, we found a significant association of XPF-rs1799801 with a reduced cancer risk in Caucasian populations (4,845 cases and 5,556 controls; recessive model: OR = 0.87, 95{\%} CI = 0.76-1.00, P = 0.049, P = 0.723 for heterogeneity test, I2 = 0). Further genotype-phenotype correlation analysis showed that the homozygous variant CC genotype carriers had higher XPF expression levels than that of the TT genotype carriers (Student's t test for a recessive model: P = 0.046). No publication bias was found by using the funnel plot and Egger's test. Conclusion: This meta-analysis suggests a lack of statistical evidence for the association between the four XPF SNPs and overall risk of cancers. However, XPF-rs1799801 may be associated with cancer risk in Caucasian populations, which needs to be further validated in single large, well-designed prospective studies.",
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AU - Zhou, Xiao Yan

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AB - Background: Xeroderma pigmentosum complementation group F (XPF or ERCC4) plays a key role in DNA repair that protects against genetic instability and carcinogenesis. A series of epidemiological studies have examined associations between XPF polymorphisms and cancer risk, but the findings remain inconclusive. Methodology/Principal Findings: In this meta-analysis of 47,639 cancer cases and 51,915 controls, by searching three electronic databases (i.e., MEDLINE, EMBASE and CNKI), we summarized 43 case-control studies from 29 publications on four commonly studied polymorphisms of XPF (i.e., rs1800067, rs1799801, rs2020955 and rs744154), and we did not find statistical evidence of any significant association with overall cancer risk. However, in stratification analyses, we found a significant association of XPF-rs1799801 with a reduced cancer risk in Caucasian populations (4,845 cases and 5,556 controls; recessive model: OR = 0.87, 95% CI = 0.76-1.00, P = 0.049, P = 0.723 for heterogeneity test, I2 = 0). Further genotype-phenotype correlation analysis showed that the homozygous variant CC genotype carriers had higher XPF expression levels than that of the TT genotype carriers (Student's t test for a recessive model: P = 0.046). No publication bias was found by using the funnel plot and Egger's test. Conclusion: This meta-analysis suggests a lack of statistical evidence for the association between the four XPF SNPs and overall risk of cancers. However, XPF-rs1799801 may be associated with cancer risk in Caucasian populations, which needs to be further validated in single large, well-designed prospective studies.

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