Association of alcohol craving with α-synuclein (SNCA)

Tatiana Foroud, Leah Flury Wetherill, Tiebing Liang, Danielle M. Dick, Victor Hesselbrock, John Kramer, John Nurnberger, Marc Schuckit, Lucinda Carr, Bernice Porjesz, Xiaoling Xuei, Howard J. Edenberg

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Background: Studies have found that genomic variation in the gene SNCA, which encodes the protein α-synuclein, may contribute to the variation in alcohol consumption in an inbred rat model of alcohol preference. Studies in humans have provided support for an association between SNCA and craving for alcohol. Methods: To examine the role of this gene in alcohol dependence and related phenotypes, 30 single nucleotide polymorphisms (SNPs) were genotyped across the SNCA gene in a sample of 219 multiplex alcoholic families of European American descent. Two phenotypes, alcohol dependence and alcohol craving, were analyzed using the pedigree disequilibrium test. Results: There was no evidence of association between any of the SNCA SNPs and alcohol dependence (p≥0.13). In contrast, 8 SNPs provided evidence of association (p<0.05) with the phenotype of alcohol craving. Haplotype analysis further supported evidence of an association with alcohol craving; a haplotype encompassing SNPs in intron 4 through the region downstream of the gene was overtransmitted to cravers and a second haplotype was overtransmitted to noncravers. Conclusions: These results suggest that variation in SNCA contributes to alcohol craving, a common, although not uniform, feature of alcohol dependence.

Original languageEnglish (US)
Pages (from-to)537-545
Number of pages9
JournalAlcoholism: Clinical and Experimental Research
Volume31
Issue number4
DOIs
StatePublished - Apr 1 2007

Keywords

  • Alcoholism
  • Alpha Synuclein
  • Craving
  • Family Study
  • Genetic Association
  • SNP

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

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