Association of alcohol dehydrogenase genes with alcohol-related phenotypes in a native american community sample

Ian R. Gizer, Howard J. Edenberg, David A. Gilder, Kirk C. Wilhelmsen, Cindy L. Ehlers

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Previous linkage studies, including a study of the Native American population described in the present report, have provided evidence for linkage of alcohol dependence and related traits to chromosome 4q near a cluster of alcohol dehydrogenase (ADH) genes, which encode enzymes of alcohol metabolism. Methods: The present study tested for associations between alcohol dependence and related traits and 22 single-nucleotide polymorphisms (SNPs) spanning the 7 ADH genes. Participants included 586 adult men and women recruited from 8 contiguous Native American reservations. A structured interview was used to assess DSM-III-R alcohol dependence criteria as well as a set of severe alcohol misuse symptoms and alcohol withdrawal symptoms. Results: No evidence for association with the alcohol dependence diagnosis was observed, but an SNP in exon 9 of ADH1B (rs2066702; ADH1B*3) and an SNP at the 5' end of ADH4 (rs3762894) showed significant evidence of association with the presence of withdrawal symptoms (p=0.0018 and 0.0012, respectively). Further, a haplotype analysis of these 2 SNPs suggested that the haplotypes containing either of the minor alleles were protective against alcohol withdrawal relative to the ancestral haplotype (p=0.000006). Conclusions: These results suggest that variants in the ADH1B and ADH4 genes may be protective against the development of some symptoms associated with alcohol dependence.

Original languageEnglish (US)
Pages (from-to)2008-2018
Number of pages11
JournalAlcoholism: Clinical and Experimental Research
Volume35
Issue number11
DOIs
StatePublished - Nov 1 2011

Fingerprint

North American Indians
Alcohol Dehydrogenase
Alcoholism
Genes
Alcohols
Single Nucleotide Polymorphism
Phenotype
Haplotypes
Substance Withdrawal Syndrome
Polymorphism
Nucleotides
Diagnostic and Statistical Manual of Mental Disorders
Exons
Chromosomes
Alleles
Interviews
Metabolism
Enzymes
Population

Keywords

  • Alcohol dehydrogenase
  • Alcohol dependence
  • Alcohol withdrawal
  • Candidate gene analysis
  • Genetic association

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology

Cite this

Association of alcohol dehydrogenase genes with alcohol-related phenotypes in a native american community sample. / Gizer, Ian R.; Edenberg, Howard J.; Gilder, David A.; Wilhelmsen, Kirk C.; Ehlers, Cindy L.

In: Alcoholism: Clinical and Experimental Research, Vol. 35, No. 11, 01.11.2011, p. 2008-2018.

Research output: Contribution to journalArticle

Gizer, Ian R. ; Edenberg, Howard J. ; Gilder, David A. ; Wilhelmsen, Kirk C. ; Ehlers, Cindy L. / Association of alcohol dehydrogenase genes with alcohol-related phenotypes in a native american community sample. In: Alcoholism: Clinical and Experimental Research. 2011 ; Vol. 35, No. 11. pp. 2008-2018.
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