Association of Borderline Pulmonary Hypertension With Mortality and Hospitalization in a Large Patient Cohort: Insights From the VA-CART Program

Bradley A. Maron, Edward Hess, Thomas M. Maddox, Alexander R. Opotowsky, Ryan J. Tedford, Tim Lahm, Karen E. Joynt, Daniel J. Kass, Thomas Stephens, Maggie A. Stanislawski, Erik R. Swenson, Ronald H. Goldstein, Jane A. Leopold, Roham T. Zamanian, Jean M. Elwing, Mary E. Plomondon, Gary K. Grunwald, Anna E. Barón, John Rumsfeld, Gaurav Choudhary

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98 Scopus citations

Abstract

BACKGROUND—: Pulmonary hypertension (PH) is associated with increased morbidity across the cardiopulmonary disease spectrum. Based largely on expert consensus opinion, PH is defined by a mean pulmonary artery pressure (mPAP) ≥25 mmHg. Although mPAP levels below this threshold are common among populations at risk for PH, the relevance of mPAP 15 mmHg, pulmonary vascular resistance ≥3.0 Wood units, or inpatient status at the time of RHC. CONCLUSIONS—: These data illustrate a continuum of risk according to mPAP level, and that borderline PH is associated with increased mortality and hospitalization. Future investigations are needed to test the generalizability of our findings to other populations and study the effect of treatment on outcome in borderline PH.

Original languageEnglish (US)
JournalCirculation
DOIs
StateAccepted/In press - Feb 15 2016

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ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Maron, B. A., Hess, E., Maddox, T. M., Opotowsky, A. R., Tedford, R. J., Lahm, T., Joynt, K. E., Kass, D. J., Stephens, T., Stanislawski, M. A., Swenson, E. R., Goldstein, R. H., Leopold, J. A., Zamanian, R. T., Elwing, J. M., Plomondon, M. E., Grunwald, G. K., Barón, A. E., Rumsfeld, J., & Choudhary, G. (Accepted/In press). Association of Borderline Pulmonary Hypertension With Mortality and Hospitalization in a Large Patient Cohort: Insights From the VA-CART Program. Circulation. https://doi.org/10.1161/CIRCULATIONAHA.115.020207