Association of Cerebral Palsy With Other Disabilities in Children With Perinatal Arterial Ischemic Stroke

Meredith Golomb, Chandan Saha, Bhuwan P. Garg, Faouzi Azzouz, Linda Williams

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Abstract

The association of cerebral palsy with other disabilities in children with perinatal stroke has not been well-studied. We examined this association in 111 children with perinatal stroke: 67 with neonatal presentation, and 44 with delayed presentation. Seventy-six children (68%) had cerebral palsy, which was hemiplegic in 66 and tri- or quadriplegic in 10. Fifty-five (72%) children with cerebral palsy had at least one other disability: 45 (59%) had a cognitive/speech impairment (moderate-severe in 20), and 36 (47%) had epilepsy (moderate-severe in 11). In children with neonatal presentation, cerebral palsy was associated with epilepsy (P = 0.0076) and cognitive impairment (P = 0.0001). These associations could not be tested in children with delayed presentation because almost all children in this group had cerebral palsy. In another analysis with multivariate logistic regression for children with cerebral palsy, children who had both neonatal presentation and history of cesarean-section delivery were more likely to have epilepsy (P = 0.001). Children with cerebral palsy after perinatal stroke who had neonatal presentation were more likely to have severe cognitive impairment (odds ratio, 7.78; 95% confidence interval, 1.80-47.32) or severe epilepsy (odds ratio, 6.64; 95% confidence interval, 1.21-69.21) than children with delayed presentation. Children with cerebral palsy after perinatal stroke are likely to have an additional disability; those with neonatal presentation are more likely to have a severe disability.

Original languageEnglish
Pages (from-to)245-249
Number of pages5
JournalPediatric Neurology
Volume37
Issue number4
DOIs
StatePublished - Oct 2007

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Disabled Children
Cerebral Palsy
Stroke
Epilepsy
Odds Ratio
Confidence Intervals
Cesarean Section
Multivariate Analysis
Logistic Models

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

Association of Cerebral Palsy With Other Disabilities in Children With Perinatal Arterial Ischemic Stroke. / Golomb, Meredith; Saha, Chandan; Garg, Bhuwan P.; Azzouz, Faouzi; Williams, Linda.

In: Pediatric Neurology, Vol. 37, No. 4, 10.2007, p. 245-249.

Research output: Contribution to journalArticle

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