Association of chlamydia trachomatis infection with redetection of human papillomavirus after apparent clearance

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Background. Persistent infection with oncogenic human papillomavirus (HPV) is associated with an increased risk of cervical malignancy. Redetection of type-specific HPV after a period of nondetection may be caused by reactivation of a low-level persistent infection. Little is known about factors associated with type-specific HPV redetection.Methods. For a longitudinal cohort of adolescent women with frequent behavioral and sexually transmitted infection (STI) information (every 3 months), Cox proportional hazard models were used to assess the influence of sexual behaviors and STIs on the redetection of oncogenic or high-risk HPV infections.Results. A total of 210 type-specific high-risk HPV detection episode periods were identified in this longitudinal cohort; 71 (33.8%) were characterized by a period of nondetection followed by redetection. Chlamydia trachomatis (hazard ratio [HR], 3.14; 95% confidence interval [CI], 1.44-6.86) was associated with redetection; redetection was >2 times more likely with each additional self-reported sex partner in the past 3 months (HR, 2.26; 95% CI, 1.35-3.78).Conclusions. This study demonstrates the role of C. trachomatis and number of recent sexual partners in type-specific HPV redetection. Given that persistent oncogenic HPV infections are associated with cancer-related outcomes, understanding the potential role of such factors in the pathogenesis of HPV-related outcomes is important.

Original languageEnglish (US)
Pages (from-to)1416-1421
Number of pages6
JournalJournal of Infectious Diseases
Volume208
Issue number9
DOIs
StatePublished - Nov 1 2013

Keywords

  • chlamydia
  • HPV redetection
  • human papillomavirus

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

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