Association of CHRM2 with IQ: Converging evidence for a gene influencing intelligence

Danielle M. Dick, Fazil Aliev, John Kramer, Jen C. Wang, Anthony Hinrichs, Sarah Bertelsen, Sam Kuperman, Marc Schuckit, John Nurnberger, Howard Edenberg, Bernice Porjesz, Henri Begleiter, Victor Hesselbrock, Alison Goate, Laura Bierut

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The cholinergic neurotransmitter system is thought to be involved in many aspects of memory, attention, and higher cognition. In the Collaborative Study on the Genetics of Alcoholism (COGA) sample, we have previously reported linkage and association to the cholinergic muscarinic 2 receptor gene (CHRM2) on chromosome 7 with evoked EEG oscillations (Jones et al. 2004), providing evidence that this gene may be involved in human brain dynamics and cognition. In addition, a small number of genetic markers were genotyped in CHRM2 in the Minnesota Twin and Family Study (Comings et al. 2003) and a Dutch family study (Gosso et al. 2006, in press) and both research groups found evidence that this gene may be involved in intelligence. In the COGA sample, we have extensively genotyped SNPs within and flanking the CHRM2 gene. We find evidence of association with multiple SNPs across CHRM2 and Performance IQ, as measured by the Wechsler Adult Intelligence Scale-Revised (WAIS-R). These results remain significant after taking into account alcohol dependence and depression diagnoses in the sample.

Original languageEnglish
Pages (from-to)265-272
Number of pages8
JournalBehavior Genetics
Volume37
Issue number2
DOIs
StatePublished - Mar 2007

Fingerprint

cholinergic agents
Muscarinic Receptors
Intelligence
Cholinergic Agents
receptors
gene
Genes
alcohol abuse
Alcoholism
genes
family studies
cognition
Cognition
Single Nucleotide Polymorphism
Twin Studies
Chromosomes, Human, Pair 7
genetic marker
neurotransmitters
Genetic Markers
sampling

Keywords

  • Association analyses
  • CHRM2
  • Cognitive ability
  • Genetics
  • Intelligence
  • IQ

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Behavioral Neuroscience
  • Psychology(all)

Cite this

Dick, D. M., Aliev, F., Kramer, J., Wang, J. C., Hinrichs, A., Bertelsen, S., ... Bierut, L. (2007). Association of CHRM2 with IQ: Converging evidence for a gene influencing intelligence. Behavior Genetics, 37(2), 265-272. https://doi.org/10.1007/s10519-006-9131-2

Association of CHRM2 with IQ : Converging evidence for a gene influencing intelligence. / Dick, Danielle M.; Aliev, Fazil; Kramer, John; Wang, Jen C.; Hinrichs, Anthony; Bertelsen, Sarah; Kuperman, Sam; Schuckit, Marc; Nurnberger, John; Edenberg, Howard; Porjesz, Bernice; Begleiter, Henri; Hesselbrock, Victor; Goate, Alison; Bierut, Laura.

In: Behavior Genetics, Vol. 37, No. 2, 03.2007, p. 265-272.

Research output: Contribution to journalArticle

Dick, DM, Aliev, F, Kramer, J, Wang, JC, Hinrichs, A, Bertelsen, S, Kuperman, S, Schuckit, M, Nurnberger, J, Edenberg, H, Porjesz, B, Begleiter, H, Hesselbrock, V, Goate, A & Bierut, L 2007, 'Association of CHRM2 with IQ: Converging evidence for a gene influencing intelligence', Behavior Genetics, vol. 37, no. 2, pp. 265-272. https://doi.org/10.1007/s10519-006-9131-2
Dick DM, Aliev F, Kramer J, Wang JC, Hinrichs A, Bertelsen S et al. Association of CHRM2 with IQ: Converging evidence for a gene influencing intelligence. Behavior Genetics. 2007 Mar;37(2):265-272. https://doi.org/10.1007/s10519-006-9131-2
Dick, Danielle M. ; Aliev, Fazil ; Kramer, John ; Wang, Jen C. ; Hinrichs, Anthony ; Bertelsen, Sarah ; Kuperman, Sam ; Schuckit, Marc ; Nurnberger, John ; Edenberg, Howard ; Porjesz, Bernice ; Begleiter, Henri ; Hesselbrock, Victor ; Goate, Alison ; Bierut, Laura. / Association of CHRM2 with IQ : Converging evidence for a gene influencing intelligence. In: Behavior Genetics. 2007 ; Vol. 37, No. 2. pp. 265-272.
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