Association of clusterin gene polymorphisms with late-onset Alzheimer's disease

Huiying Gu, Xing Wei, Shirley Chen, Alexander Kurz, Ulrich Müller, Thomas Gasser, Richard C. Dodel, Martin Farlow, Yansheng Du

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background/Aims: Some studies have implicated the role of apolipoprotein J [clusterin (CLU), apoJ] in the pathogenesis of Alzheimer's disease (AD). In this study, we investigated the polymorphisms rs11136000 and rs9331888 within CLU in late-onset sporadic AD (LOAD) patients and nondemented subjects. Methods: LOAD patients and control subjects were analyzed. Genotyping of rs11136000 and rs9331888 was performed using standard PCR following different restriction endonuclease digestion. Results: Although there were no significant differences in genotype frequencies of these two polymorphisms, the haplotype CG was associated with a statistically significantly increased LOAD risk. Conclusion: The rs11136000 and rs9331888 polymorphisms of the CLU gene are associated with LOAD.

Original languageEnglish
Pages (from-to)198-201
Number of pages4
JournalDementia and Geriatric Cognitive Disorders
Volume32
Issue number3
DOIs
StatePublished - Dec 2011

Fingerprint

Clusterin
Alzheimer Disease
Genes
DNA Restriction Enzymes
Haplotypes
Digestion
Genotype
Polymerase Chain Reaction

Keywords

  • Alzheimer's disease, late-onset
  • Apolipoprotein J
  • Clusterin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Cognitive Neuroscience

Cite this

Association of clusterin gene polymorphisms with late-onset Alzheimer's disease. / Gu, Huiying; Wei, Xing; Chen, Shirley; Kurz, Alexander; Müller, Ulrich; Gasser, Thomas; Dodel, Richard C.; Farlow, Martin; Du, Yansheng.

In: Dementia and Geriatric Cognitive Disorders, Vol. 32, No. 3, 12.2011, p. 198-201.

Research output: Contribution to journalArticle

Gu, Huiying ; Wei, Xing ; Chen, Shirley ; Kurz, Alexander ; Müller, Ulrich ; Gasser, Thomas ; Dodel, Richard C. ; Farlow, Martin ; Du, Yansheng. / Association of clusterin gene polymorphisms with late-onset Alzheimer's disease. In: Dementia and Geriatric Cognitive Disorders. 2011 ; Vol. 32, No. 3. pp. 198-201.
@article{8f045dbfface4d9db0e881156ad6e6e5,
title = "Association of clusterin gene polymorphisms with late-onset Alzheimer's disease",
abstract = "Background/Aims: Some studies have implicated the role of apolipoprotein J [clusterin (CLU), apoJ] in the pathogenesis of Alzheimer's disease (AD). In this study, we investigated the polymorphisms rs11136000 and rs9331888 within CLU in late-onset sporadic AD (LOAD) patients and nondemented subjects. Methods: LOAD patients and control subjects were analyzed. Genotyping of rs11136000 and rs9331888 was performed using standard PCR following different restriction endonuclease digestion. Results: Although there were no significant differences in genotype frequencies of these two polymorphisms, the haplotype CG was associated with a statistically significantly increased LOAD risk. Conclusion: The rs11136000 and rs9331888 polymorphisms of the CLU gene are associated with LOAD.",
keywords = "Alzheimer's disease, late-onset, Apolipoprotein J, Clusterin",
author = "Huiying Gu and Xing Wei and Shirley Chen and Alexander Kurz and Ulrich M{\"u}ller and Thomas Gasser and Dodel, {Richard C.} and Martin Farlow and Yansheng Du",
year = "2011",
month = "12",
doi = "10.1159/000331276",
language = "English",
volume = "32",
pages = "198--201",
journal = "Dementia and Geriatric Cognitive Disorders",
issn = "1420-8008",
publisher = "S. Karger AG",
number = "3",

}

TY - JOUR

T1 - Association of clusterin gene polymorphisms with late-onset Alzheimer's disease

AU - Gu, Huiying

AU - Wei, Xing

AU - Chen, Shirley

AU - Kurz, Alexander

AU - Müller, Ulrich

AU - Gasser, Thomas

AU - Dodel, Richard C.

AU - Farlow, Martin

AU - Du, Yansheng

PY - 2011/12

Y1 - 2011/12

N2 - Background/Aims: Some studies have implicated the role of apolipoprotein J [clusterin (CLU), apoJ] in the pathogenesis of Alzheimer's disease (AD). In this study, we investigated the polymorphisms rs11136000 and rs9331888 within CLU in late-onset sporadic AD (LOAD) patients and nondemented subjects. Methods: LOAD patients and control subjects were analyzed. Genotyping of rs11136000 and rs9331888 was performed using standard PCR following different restriction endonuclease digestion. Results: Although there were no significant differences in genotype frequencies of these two polymorphisms, the haplotype CG was associated with a statistically significantly increased LOAD risk. Conclusion: The rs11136000 and rs9331888 polymorphisms of the CLU gene are associated with LOAD.

AB - Background/Aims: Some studies have implicated the role of apolipoprotein J [clusterin (CLU), apoJ] in the pathogenesis of Alzheimer's disease (AD). In this study, we investigated the polymorphisms rs11136000 and rs9331888 within CLU in late-onset sporadic AD (LOAD) patients and nondemented subjects. Methods: LOAD patients and control subjects were analyzed. Genotyping of rs11136000 and rs9331888 was performed using standard PCR following different restriction endonuclease digestion. Results: Although there were no significant differences in genotype frequencies of these two polymorphisms, the haplotype CG was associated with a statistically significantly increased LOAD risk. Conclusion: The rs11136000 and rs9331888 polymorphisms of the CLU gene are associated with LOAD.

KW - Alzheimer's disease, late-onset

KW - Apolipoprotein J

KW - Clusterin

UR - http://www.scopus.com/inward/record.url?scp=82055200581&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82055200581&partnerID=8YFLogxK

U2 - 10.1159/000331276

DO - 10.1159/000331276

M3 - Article

VL - 32

SP - 198

EP - 201

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

SN - 1420-8008

IS - 3

ER -