Association of clusterin gene polymorphisms with late-onset Alzheimer's disease

Huiying Gu, Xing Wei, Shirley Chen, Alexander Kurz, Ulrich Müller, Thomas Gasser, Richard C. Dodel, Martin R. Farlow, Yansheng Du

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Background/Aims: Some studies have implicated the role of apolipoprotein J [clusterin (CLU), apoJ] in the pathogenesis of Alzheimer's disease (AD). In this study, we investigated the polymorphisms rs11136000 and rs9331888 within CLU in late-onset sporadic AD (LOAD) patients and nondemented subjects. Methods: LOAD patients and control subjects were analyzed. Genotyping of rs11136000 and rs9331888 was performed using standard PCR following different restriction endonuclease digestion. Results: Although there were no significant differences in genotype frequencies of these two polymorphisms, the haplotype CG was associated with a statistically significantly increased LOAD risk. Conclusion: The rs11136000 and rs9331888 polymorphisms of the CLU gene are associated with LOAD.

Original languageEnglish (US)
Pages (from-to)198-201
Number of pages4
JournalDementia and Geriatric Cognitive Disorders
Volume32
Issue number3
DOIs
StatePublished - Dec 1 2011

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Keywords

  • Alzheimer's disease, late-onset
  • Apolipoprotein J
  • Clusterin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Cognitive Neuroscience

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