Abstract
Objective: To examine the association of potentially modifiable factors such as condom use, sexual behaviors, and concurrent sexually transmitted infections with duration of genital human papillomavirus (HPV) infections among adolescent women. Design: Longitudinal observational study. Setting: Study conducted at 3 inner-city clinics in Indianapolis, Ind. Participants: Forty-nine HPV-positive adolescents were tested frequently for HPV infection and provided sexual behavior diaries. Main Exposures: Condom use, sexual behaviors, number of partners, and concurrent infections with Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis. Main Outcome Measures: Time from onset to clearance of type-specificHPVinfections was analyzed with proportional hazard models. Adjusted hazard ratios (AHRs) were used to assess the effects of risk factors on the duration of HPV infection. Because viral clearance is a preferred outcome, a variable with an AHR less than 1 was considered a risk factor (ie, associated with reduced chance of viral clearance and prolonged infection). Results: Prolonged HPV infection was associated with oncogenic HPV types (AHR, 0.58 [95% confidence interval (CI), 0.39-0.84]) less than median level of condom use during an HPV infection (AHR, 0.53 [95% CI, 0.33-0.84]) and coinfection withCtrachomatis (AHR, 0.58 [95% CI, 0.31-0.89]) or T vaginalis (AHR, 0.32 [95% CI, 0.16-0.64]). Not having multiple sexual partners during an HPV infection was associated with early HPV clearance (AHR, 5.52 [95% CI, 3.28-9.30]). Conclusions: These findings support public health messages of reducing the number of sexual partners, promoting routine condom use, and frequent sexually transmitted infection screening that may be beneficial with HPV infections.
| Original language | English |
|---|---|
| Pages (from-to) | 151-156 |
| Number of pages | 6 |
| Journal | Archives of Pediatrics and Adolescent Medicine |
| Volume | 160 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2006 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Association of condom use, sexual behaviors, and sexually transmitted infections with the duration of genital human papillomavirus infection among adolescent women. / Shew, Marcia; Fortenberry, J.; Tu, Wanzhu; Juliar, Beth E.; Batteiger, Byron; Qadadri, Brahim; Brown, Darron.
In: Archives of Pediatrics and Adolescent Medicine, Vol. 160, No. 2, 02.2006, p. 151-156.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of condom use, sexual behaviors, and sexually transmitted infections with the duration of genital human papillomavirus infection among adolescent women
AU - Shew, Marcia
AU - Fortenberry, J.
AU - Tu, Wanzhu
AU - Juliar, Beth E.
AU - Batteiger, Byron
AU - Qadadri, Brahim
AU - Brown, Darron
PY - 2006/2
Y1 - 2006/2
N2 - Objective: To examine the association of potentially modifiable factors such as condom use, sexual behaviors, and concurrent sexually transmitted infections with duration of genital human papillomavirus (HPV) infections among adolescent women. Design: Longitudinal observational study. Setting: Study conducted at 3 inner-city clinics in Indianapolis, Ind. Participants: Forty-nine HPV-positive adolescents were tested frequently for HPV infection and provided sexual behavior diaries. Main Exposures: Condom use, sexual behaviors, number of partners, and concurrent infections with Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis. Main Outcome Measures: Time from onset to clearance of type-specificHPVinfections was analyzed with proportional hazard models. Adjusted hazard ratios (AHRs) were used to assess the effects of risk factors on the duration of HPV infection. Because viral clearance is a preferred outcome, a variable with an AHR less than 1 was considered a risk factor (ie, associated with reduced chance of viral clearance and prolonged infection). Results: Prolonged HPV infection was associated with oncogenic HPV types (AHR, 0.58 [95% confidence interval (CI), 0.39-0.84]) less than median level of condom use during an HPV infection (AHR, 0.53 [95% CI, 0.33-0.84]) and coinfection withCtrachomatis (AHR, 0.58 [95% CI, 0.31-0.89]) or T vaginalis (AHR, 0.32 [95% CI, 0.16-0.64]). Not having multiple sexual partners during an HPV infection was associated with early HPV clearance (AHR, 5.52 [95% CI, 3.28-9.30]). Conclusions: These findings support public health messages of reducing the number of sexual partners, promoting routine condom use, and frequent sexually transmitted infection screening that may be beneficial with HPV infections.
AB - Objective: To examine the association of potentially modifiable factors such as condom use, sexual behaviors, and concurrent sexually transmitted infections with duration of genital human papillomavirus (HPV) infections among adolescent women. Design: Longitudinal observational study. Setting: Study conducted at 3 inner-city clinics in Indianapolis, Ind. Participants: Forty-nine HPV-positive adolescents were tested frequently for HPV infection and provided sexual behavior diaries. Main Exposures: Condom use, sexual behaviors, number of partners, and concurrent infections with Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis. Main Outcome Measures: Time from onset to clearance of type-specificHPVinfections was analyzed with proportional hazard models. Adjusted hazard ratios (AHRs) were used to assess the effects of risk factors on the duration of HPV infection. Because viral clearance is a preferred outcome, a variable with an AHR less than 1 was considered a risk factor (ie, associated with reduced chance of viral clearance and prolonged infection). Results: Prolonged HPV infection was associated with oncogenic HPV types (AHR, 0.58 [95% confidence interval (CI), 0.39-0.84]) less than median level of condom use during an HPV infection (AHR, 0.53 [95% CI, 0.33-0.84]) and coinfection withCtrachomatis (AHR, 0.58 [95% CI, 0.31-0.89]) or T vaginalis (AHR, 0.32 [95% CI, 0.16-0.64]). Not having multiple sexual partners during an HPV infection was associated with early HPV clearance (AHR, 5.52 [95% CI, 3.28-9.30]). Conclusions: These findings support public health messages of reducing the number of sexual partners, promoting routine condom use, and frequent sexually transmitted infection screening that may be beneficial with HPV infections.
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UR - http://www.scopus.com/inward/citedby.url?scp=32244441155&partnerID=8YFLogxK
U2 - 10.1001/archpedi.160.2.151
DO - 10.1001/archpedi.160.2.151
M3 - Article
C2 - 16461870
AN - SCOPUS:32244441155
VL - 160
SP - 151
EP - 156
JO - JAMA Pediatrics
JF - JAMA Pediatrics
SN - 2168-6203
IS - 2
ER -