Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample

Arpana Agrawal, Howard Edenberg, Tatiana Foroud, Laura J. Bierut, Gerald Dunne, Anthony L. Hinrichs, John Nurnberger, Raymond Crowe, Samuel Kuperman, Marc A. Schuckit, Henri Begleiter, Bernice Porjesz, Danielle M. Dick

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Results from twin studies suggest that overlapping genetic factors influence alcohol dependence and illicit drug dependence. Using data from the Collaborative Study on the Genetics of Alcoholism (COGA), we examined the association between 69 SNPs in the GABAA receptor gene cluster on chromosome 4 and marijuana and illicit drug dependence, individually, and as co-occurring phenotypes with alcohol dependence. Results suggested association between marijuana dependence and illicit drug dependence with SNPs in the GABRA2 gene. Interestingly, the evidence for association previously observed with alcohol dependence came only from individuals with comorbid illicit drug dependence. There was no association with other genes in the GABAA cluster on chromosome 4 with illicit drug dependence.

Original languageEnglish
Pages (from-to)640-650
Number of pages11
JournalBehavior Genetics
Volume36
Issue number5
DOIs
StatePublished - Sep 2006

Fingerprint

drug abuse
Street Drugs
alcohol abuse
Alcoholism
Substance-Related Disorders
drug
alcohol
Cannabis sativa
Chromosomes, Human, Pair 4
multigene family
Single Nucleotide Polymorphism
gene
chromosome
sampling
Marijuana Abuse
chromosomes
Twin Studies
GABA-A Receptors
Cannabis
Multigene Family

Keywords

  • Alcoholism
  • Association analyses
  • COGA
  • Drug dependence
  • GABRA2
  • PDT

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Behavioral Neuroscience
  • Psychology(all)

Cite this

Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. / Agrawal, Arpana; Edenberg, Howard; Foroud, Tatiana; Bierut, Laura J.; Dunne, Gerald; Hinrichs, Anthony L.; Nurnberger, John; Crowe, Raymond; Kuperman, Samuel; Schuckit, Marc A.; Begleiter, Henri; Porjesz, Bernice; Dick, Danielle M.

In: Behavior Genetics, Vol. 36, No. 5, 09.2006, p. 640-650.

Research output: Contribution to journalArticle

Agrawal, A, Edenberg, H, Foroud, T, Bierut, LJ, Dunne, G, Hinrichs, AL, Nurnberger, J, Crowe, R, Kuperman, S, Schuckit, MA, Begleiter, H, Porjesz, B & Dick, DM 2006, 'Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample', Behavior Genetics, vol. 36, no. 5, pp. 640-650. https://doi.org/10.1007/s10519-006-9069-4
Agrawal, Arpana ; Edenberg, Howard ; Foroud, Tatiana ; Bierut, Laura J. ; Dunne, Gerald ; Hinrichs, Anthony L. ; Nurnberger, John ; Crowe, Raymond ; Kuperman, Samuel ; Schuckit, Marc A. ; Begleiter, Henri ; Porjesz, Bernice ; Dick, Danielle M. / Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. In: Behavior Genetics. 2006 ; Vol. 36, No. 5. pp. 640-650.
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