Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers

Alan Breier, Anil K. Malhotra, Debra A. Pinals, Neil I. Weisenfeld, David Pickar

Research output: Contribution to journalArticle

285 Scopus citations

Abstract

Objective: Agents that antagonize the N-methyl-D-aspartic acid (NMDA) receptor, such as phencyclidine and ketamine, produce an acute psychotic state in normal individuals that resembles some symptoms of schizophrenia. The aim of this study was to determine which brain regions are involved in NMDA receptor-mediated psychosis. Method: Positron emission tomography with [18F]fluorodeoxyglucose was used to determine cerebral metabolic activity in 17 healthy volunteers while an acute psychotic state was induced simultaneously by the administration of subanesthetic doses of ketamine. Results: Ketamine produced focal increases in metabolic activity in the prefrontal cortex and an acute psychotic state. A change in one psychotic symptom, conceptual disorganization, was significantly related to prefrontal activation. Conclusions: These data suggest that the prefrontal cortex may be involved in mediating NMDA receptor-induced psychosis.

Original languageEnglish (US)
Pages (from-to)805-811
Number of pages7
JournalAmerican Journal of Psychiatry
Volume154
Issue number6
DOIs
StatePublished - Jun 1997
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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