Association of leptin and hunger-satiety ratings in obese women

A. F. Heini, C. Lara-Castro, K. A. Kirk, Robert Considine, J. F. Caro, R. L. Weinsier

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

OBJECTIVE: To measure leptin, insulin and cholecystokinin (CCK) concentrations in obese women on calorie restriction and to determine their correlation with hunger-satiety ratings. Although it has been proposed to play a role in appetite regulation, the effects of physiological concentrations of these hormones on hunger-satiety in humans have not yet been well established. DESIGN: Prospective metabolic study. A two week 'wash-in period' followed by a three-week observation period, during which each subject underwent six measurements of satiety, blood parameters and body weight. SETTING: Energy Metabolism Research Unit, Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA. SUBJECTS: 22 moderately to severely overweight women (mean age: 45 ± 8 y; body mass index (BMI): 33 ± 6 kg/m2). INTERVENTION: Energy restriction, in the form of a 3.3 MJ (800 kcal) diet during five weeks. MAIN OUTCOME MEASUREMENTS: Fasting blood levels of leptin, insulin, glucose and CCK, fasting hunger-satiety scores and body weight. RESULTS: The mean (± s.d.) fasting serum leptin concentration at the beginning of the observation period was 26.1 ± 15.9 ng/ml (range: 6.7-59.8 ng/ml). Leptin concentrations correlated positively with body weight (P <0.0001). Furthermore, reductions in body weight were associated with decreases in fasting leptin levels (P = 0.002). Leptin concentrations correlated with serum levels of insulin (P = 0.0001) and CCK (P = 0.06), but in multivariate analysis including insulin, CCK and glucose, only leptin had a significant relationship with satiety (P = 0.04). This relationship was linear. CONCLUSIONS: These results confirm the association between leptin levels, body weight and serum insulin. We also showed that higher serum leptin levels correlated with greater feelings of fullness, a relationship which was not blunted in the more obese subjects. These findings suggest that leptin is a satiety hormone that reduces appetite, even in obese individuals, and that weight gain must be due to other factors, overriding this feed-back regulation.

Original languageEnglish (US)
Pages (from-to)1084-1087
Number of pages4
JournalInternational Journal of Obesity
Volume22
Issue number11
StatePublished - 1998
Externally publishedYes

Fingerprint

Hunger
hunger
satiety
Leptin
leptin
cholecystokinin
Cholecystokinin
blood serum
insulin
Body Weight
fasting
Insulin
Fasting
body weight
appetite
Serum
Nutritional Sciences
hormones
Observation
Hormones

Keywords

  • Appetite regulation
  • Body weight
  • Cholecystokinin
  • Hormone
  • Insulin
  • Leptin
  • Obesity
  • Satiety

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Heini, A. F., Lara-Castro, C., Kirk, K. A., Considine, R., Caro, J. F., & Weinsier, R. L. (1998). Association of leptin and hunger-satiety ratings in obese women. International Journal of Obesity, 22(11), 1084-1087.

Association of leptin and hunger-satiety ratings in obese women. / Heini, A. F.; Lara-Castro, C.; Kirk, K. A.; Considine, Robert; Caro, J. F.; Weinsier, R. L.

In: International Journal of Obesity, Vol. 22, No. 11, 1998, p. 1084-1087.

Research output: Contribution to journalArticle

Heini, AF, Lara-Castro, C, Kirk, KA, Considine, R, Caro, JF & Weinsier, RL 1998, 'Association of leptin and hunger-satiety ratings in obese women', International Journal of Obesity, vol. 22, no. 11, pp. 1084-1087.
Heini AF, Lara-Castro C, Kirk KA, Considine R, Caro JF, Weinsier RL. Association of leptin and hunger-satiety ratings in obese women. International Journal of Obesity. 1998;22(11):1084-1087.
Heini, A. F. ; Lara-Castro, C. ; Kirk, K. A. ; Considine, Robert ; Caro, J. F. ; Weinsier, R. L. / Association of leptin and hunger-satiety ratings in obese women. In: International Journal of Obesity. 1998 ; Vol. 22, No. 11. pp. 1084-1087.
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AU - Heini, A. F.

AU - Lara-Castro, C.

AU - Kirk, K. A.

AU - Considine, Robert

AU - Caro, J. F.

AU - Weinsier, R. L.

PY - 1998

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N2 - OBJECTIVE: To measure leptin, insulin and cholecystokinin (CCK) concentrations in obese women on calorie restriction and to determine their correlation with hunger-satiety ratings. Although it has been proposed to play a role in appetite regulation, the effects of physiological concentrations of these hormones on hunger-satiety in humans have not yet been well established. DESIGN: Prospective metabolic study. A two week 'wash-in period' followed by a three-week observation period, during which each subject underwent six measurements of satiety, blood parameters and body weight. SETTING: Energy Metabolism Research Unit, Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA. SUBJECTS: 22 moderately to severely overweight women (mean age: 45 ± 8 y; body mass index (BMI): 33 ± 6 kg/m2). INTERVENTION: Energy restriction, in the form of a 3.3 MJ (800 kcal) diet during five weeks. MAIN OUTCOME MEASUREMENTS: Fasting blood levels of leptin, insulin, glucose and CCK, fasting hunger-satiety scores and body weight. RESULTS: The mean (± s.d.) fasting serum leptin concentration at the beginning of the observation period was 26.1 ± 15.9 ng/ml (range: 6.7-59.8 ng/ml). Leptin concentrations correlated positively with body weight (P <0.0001). Furthermore, reductions in body weight were associated with decreases in fasting leptin levels (P = 0.002). Leptin concentrations correlated with serum levels of insulin (P = 0.0001) and CCK (P = 0.06), but in multivariate analysis including insulin, CCK and glucose, only leptin had a significant relationship with satiety (P = 0.04). This relationship was linear. CONCLUSIONS: These results confirm the association between leptin levels, body weight and serum insulin. We also showed that higher serum leptin levels correlated with greater feelings of fullness, a relationship which was not blunted in the more obese subjects. These findings suggest that leptin is a satiety hormone that reduces appetite, even in obese individuals, and that weight gain must be due to other factors, overriding this feed-back regulation.

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KW - Body weight

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KW - Insulin

KW - Leptin

KW - Obesity

KW - Satiety

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