Association of lower airway inflammation with physiologic findings in young children with cystic fibrosis

Stacey L. Peterson-Carmichael, William T. Harris, Ruchika Goel, Terry L. Noah, Robin Johnson, Margaret W. Leigh, Stephanie D. Davis

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Background: The relationship between lower airway markers of inflammation and infection with physiologic findings is poorly understood in young children with cystic fibrosis (CF). The goal of this study was to evaluate the association of bronchoalveolar lavage fluid (BALF) markers of infection and inflammation, including mediators linked to airway remodeling, to infant lung function values in young children with CF undergoing clinically indicated bronchoscopy. Methods: Plethysmography and the raised volume rapid thoracoabdominal compression (RVRTC) technique were performed in 16 sedated infants and young children with CF prior to bronchoscopy BALF was collected and analyzed for pathogen density, cell count, % neutrophils, transforming growth factor beta 1 (TGF-Pi), matrix metalloproteinases (MMP), and interleukin-8 (IL-8). Results: There was a significant direct correlation between functional residual capacity (FRC), the ratio of residual volume to total lung capacity (RV/TLC) and FRC/TLC with % neutrophils (P< 0.05). Forced expiratory flows were inversely correlated to % neutrophils (P< 0.01). Lung function parameters did not differentiate those with and without lower airway infection; however, pathogen density directly correlated with FRC and inversely correlated with flows (P< 0.05). In a subset of the population, MMP-2 directly correlated with RV/TLC and inversely correlated with flows (P< 0.05) and TGF-p1 directly correlated with FRC (P< 0.05). Conclusions: Results from this study suggest that lower airway inflammation as well as mediators linked to airway remodeling play an active role in pulmonary deterioration in CF infants and young children undergoing clinically indicated bronchoscopy

Original languageEnglish (US)
Pages (from-to)503-511
Number of pages9
JournalPediatric pulmonology
Volume44
Issue number5
DOIs
StatePublished - May 1 2009

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Keywords

  • Bronchoalveolar lavage
  • Bronchoscopy
  • Cystic fibrosis
  • Forced expiratory flows
  • Infant pulmonary function tests
  • Plethysmography
  • Raised volume technique

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Peterson-Carmichael, S. L., Harris, W. T., Goel, R., Noah, T. L., Johnson, R., Leigh, M. W., & Davis, S. D. (2009). Association of lower airway inflammation with physiologic findings in young children with cystic fibrosis. Pediatric pulmonology, 44(5), 503-511. https://doi.org/10.1002/ppul.21044