Association of maternal lithium exposure and premature delivery.

W. A. Troyer, G. R. Pereira, R. A. Lannon, J. Belik, Mervin Yoder

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Lithium is widely used and the treatment of choice for patients with manic-depressive illness. For pregnant patients with manic-depressive illness, however, the use of lithium during the first trimester of pregnancy may present an increased risk for fetal maldevelopment. We have recently cared for several large-for-gestational-age, prematurely born infants whose mothers were treated with lithium throughout pregnancy. To determine whether maternal lithium use during pregnancy may predispose to the onset of premature labor and fetal macrosomia, we reviewed records from the International Register of Lithium Babies and from a cohort of manic-depressive pregnant women. More than one third (36%) of infants reported to the International Register were born prematurely, and 37% of the premature infants were large for gestational age; 15% of the term infants were born large for gestational age. In the cohort group, manic-depressive mothers who received lithium during pregnancy had a 2.5-fold higher incidence of premature births than manic-depressive pregnant patients who did not receive lithium treatment. The incidence of large-for-gestational-age births in lithium-treated women in the cohort was not different from that of the general population or from manic-depressive women not treated with lithium. In summary, an association between maternal lithium therapy and premature delivery is reported. We recommend that women receiving lithium therapy during pregnancy be closely monitored for the onset of premature labor.

Original languageEnglish
Pages (from-to)123-127
Number of pages5
JournalJournal of Perinatology
Volume13
Issue number2
StatePublished - Mar 1993

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Maternal Exposure
Lithium
Gestational Age
Mothers
Pregnancy
Premature Obstetric Labor
Fetal Macrosomia
Incidence
Premature Birth
First Pregnancy Trimester
Therapeutics
Premature Infants
Pregnant Women
Parturition

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Troyer, W. A., Pereira, G. R., Lannon, R. A., Belik, J., & Yoder, M. (1993). Association of maternal lithium exposure and premature delivery. Journal of Perinatology, 13(2), 123-127.

Association of maternal lithium exposure and premature delivery. / Troyer, W. A.; Pereira, G. R.; Lannon, R. A.; Belik, J.; Yoder, Mervin.

In: Journal of Perinatology, Vol. 13, No. 2, 03.1993, p. 123-127.

Research output: Contribution to journalArticle

Troyer, WA, Pereira, GR, Lannon, RA, Belik, J & Yoder, M 1993, 'Association of maternal lithium exposure and premature delivery.', Journal of Perinatology, vol. 13, no. 2, pp. 123-127.
Troyer WA, Pereira GR, Lannon RA, Belik J, Yoder M. Association of maternal lithium exposure and premature delivery. Journal of Perinatology. 1993 Mar;13(2):123-127.
Troyer, W. A. ; Pereira, G. R. ; Lannon, R. A. ; Belik, J. ; Yoder, Mervin. / Association of maternal lithium exposure and premature delivery. In: Journal of Perinatology. 1993 ; Vol. 13, No. 2. pp. 123-127.
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